Gut microbiome and bladder cancer: A new link through nitrosamine metabolism
A recent Nature paper1 reveals that gut microbes metabolize N-butyl-N-(4-hydroxybutyl)-nitrosamine (BBN) into the bladder carcinogen N-n-butyl-N-(3-carboxypropyl)-nitrosamine (BCPN) in the intestines, establishing a direct link between gut microbial activity and the development of bladder cancer. A...
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| Veröffentlicht in: | Cell host & microbe 2024-10, Vol.32 (10), p.1637-1639 |
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| creator | Mani, Sridhar |
| description | A recent Nature paper1 reveals that gut microbes metabolize N-butyl-N-(4-hydroxybutyl)-nitrosamine (BBN) into the bladder carcinogen N-n-butyl-N-(3-carboxypropyl)-nitrosamine (BCPN) in the intestines, establishing a direct link between gut microbial activity and the development of bladder cancer.
A recent Nature paper reveals that gut microbes metabolize N-butyl-N-(4-hydroxybutyl)-nitrosamine (BBN) into the bladder carcinogen N-n-butyl-N-(3-carboxypropyl)-nitrosamine (BCPN) in the intestines, establishing a direct link between gut microbial activity and the development of bladder cancer. |
| doi_str_mv | 10.1016/j.chom.2024.09.003 |
| format | Article |
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A recent Nature paper reveals that gut microbes metabolize N-butyl-N-(4-hydroxybutyl)-nitrosamine (BBN) into the bladder carcinogen N-n-butyl-N-(3-carboxypropyl)-nitrosamine (BCPN) in the intestines, establishing a direct link between gut microbial activity and the development of bladder cancer.</description><identifier>ISSN: 1931-3128</identifier><identifier>ISSN: 1934-6069</identifier><identifier>EISSN: 1934-6069</identifier><identifier>DOI: 10.1016/j.chom.2024.09.003</identifier><identifier>PMID: 39389023</identifier><language>eng</language><publisher>United States: Elsevier Inc</publisher><subject>Animals ; Butylhydroxybutylnitrosamine - metabolism ; Carcinogens - metabolism ; Carcinogens - toxicity ; Gastrointestinal Microbiome - physiology ; Humans ; Mice ; Nitrosamines - metabolism ; Urinary Bladder Neoplasms - metabolism ; Urinary Bladder Neoplasms - microbiology</subject><ispartof>Cell host & microbe, 2024-10, Vol.32 (10), p.1637-1639</ispartof><rights>2024 Elsevier Inc.</rights><rights>Copyright © 2024 Elsevier Inc. All rights reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c237t-d6f5caeafcad811359ec293f1047fb9666226ddf4ba770e9a93b54d53bdff4a63</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S1931312824003470$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3537,27901,27902,65306</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/39389023$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Mani, Sridhar</creatorcontrib><title>Gut microbiome and bladder cancer: A new link through nitrosamine metabolism</title><title>Cell host & microbe</title><addtitle>Cell Host Microbe</addtitle><description>A recent Nature paper1 reveals that gut microbes metabolize N-butyl-N-(4-hydroxybutyl)-nitrosamine (BBN) into the bladder carcinogen N-n-butyl-N-(3-carboxypropyl)-nitrosamine (BCPN) in the intestines, establishing a direct link between gut microbial activity and the development of bladder cancer.
A recent Nature paper reveals that gut microbes metabolize N-butyl-N-(4-hydroxybutyl)-nitrosamine (BBN) into the bladder carcinogen N-n-butyl-N-(3-carboxypropyl)-nitrosamine (BCPN) in the intestines, establishing a direct link between gut microbial activity and the development of bladder cancer.</description><subject>Animals</subject><subject>Butylhydroxybutylnitrosamine - metabolism</subject><subject>Carcinogens - metabolism</subject><subject>Carcinogens - toxicity</subject><subject>Gastrointestinal Microbiome - physiology</subject><subject>Humans</subject><subject>Mice</subject><subject>Nitrosamines - metabolism</subject><subject>Urinary Bladder Neoplasms - metabolism</subject><subject>Urinary Bladder Neoplasms - microbiology</subject><issn>1931-3128</issn><issn>1934-6069</issn><issn>1934-6069</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2024</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kMtO5DAQRS00iPcPsEBezibBj8Rpo9kgxEtqiQ2sLccu027iGOwExN_jpplZzqaqFqeudA9Cp5TUlFBxvq7NKoaaEdbURNaE8B10QCVvKkGE_PV904pTtthHhzmvCWlb0tE9tM8lX0jC-AFa3s4TDt6k2PsYAOvR4n7Q1kLCRo8G0gW-xCN84MGPL3hapTg_r_DopxSzDn4EHGDSfRx8Dsdo1-khw8nPPkJPN9ePV3fV8uH2_upyWRnGu6mywrVGg3ZG2wWlvJVgmOSOkqZzvRRCMCasdU2vu46A1JL3bWNb3lvnGi34Efq9zX1N8W2GPKngs4Fh0CPEOStOaWlKyiwo26KlYc4JnHpNPuj0qShRG4tqrTYW1caiIlIVi-Xp7Cd_7gPYfy9_tRXgzxaA0vLdQ1LZeCi2rE9gJmWj_1_-F590g-M</recordid><startdate>20241009</startdate><enddate>20241009</enddate><creator>Mani, Sridhar</creator><general>Elsevier Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20241009</creationdate><title>Gut microbiome and bladder cancer: A new link through nitrosamine metabolism</title><author>Mani, Sridhar</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c237t-d6f5caeafcad811359ec293f1047fb9666226ddf4ba770e9a93b54d53bdff4a63</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2024</creationdate><topic>Animals</topic><topic>Butylhydroxybutylnitrosamine - metabolism</topic><topic>Carcinogens - metabolism</topic><topic>Carcinogens - toxicity</topic><topic>Gastrointestinal Microbiome - physiology</topic><topic>Humans</topic><topic>Mice</topic><topic>Nitrosamines - metabolism</topic><topic>Urinary Bladder Neoplasms - metabolism</topic><topic>Urinary Bladder Neoplasms - microbiology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Mani, Sridhar</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Cell host & microbe</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Mani, Sridhar</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Gut microbiome and bladder cancer: A new link through nitrosamine metabolism</atitle><jtitle>Cell host & microbe</jtitle><addtitle>Cell Host Microbe</addtitle><date>2024-10-09</date><risdate>2024</risdate><volume>32</volume><issue>10</issue><spage>1637</spage><epage>1639</epage><pages>1637-1639</pages><issn>1931-3128</issn><issn>1934-6069</issn><eissn>1934-6069</eissn><abstract>A recent Nature paper1 reveals that gut microbes metabolize N-butyl-N-(4-hydroxybutyl)-nitrosamine (BBN) into the bladder carcinogen N-n-butyl-N-(3-carboxypropyl)-nitrosamine (BCPN) in the intestines, establishing a direct link between gut microbial activity and the development of bladder cancer.
A recent Nature paper reveals that gut microbes metabolize N-butyl-N-(4-hydroxybutyl)-nitrosamine (BBN) into the bladder carcinogen N-n-butyl-N-(3-carboxypropyl)-nitrosamine (BCPN) in the intestines, establishing a direct link between gut microbial activity and the development of bladder cancer.</abstract><cop>United States</cop><pub>Elsevier Inc</pub><pmid>39389023</pmid><doi>10.1016/j.chom.2024.09.003</doi><tpages>3</tpages></addata></record> |
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| ispartof | Cell host & microbe, 2024-10, Vol.32 (10), p.1637-1639 |
| issn | 1931-3128 1934-6069 1934-6069 |
| language | eng |
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| source | MEDLINE; Elsevier ScienceDirect Journals Complete |
| subjects | Animals Butylhydroxybutylnitrosamine - metabolism Carcinogens - metabolism Carcinogens - toxicity Gastrointestinal Microbiome - physiology Humans Mice Nitrosamines - metabolism Urinary Bladder Neoplasms - metabolism Urinary Bladder Neoplasms - microbiology |
| title | Gut microbiome and bladder cancer: A new link through nitrosamine metabolism |
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