Gut microbiome and bladder cancer: A new link through nitrosamine metabolism

A recent Nature paper1 reveals that gut microbes metabolize N-butyl-N-(4-hydroxybutyl)-nitrosamine (BBN) into the bladder carcinogen N-n-butyl-N-(3-carboxypropyl)-nitrosamine (BCPN) in the intestines, establishing a direct link between gut microbial activity and the development of bladder cancer. A...

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Veröffentlicht in:	Cell host & microbe 2024-10, Vol.32 (10), p.1637-1639
1. Verfasser:	Mani, Sridhar
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Butylhydroxybutylnitrosamine - metabolism Carcinogens - metabolism Carcinogens - toxicity Gastrointestinal Microbiome - physiology Humans Mice Nitrosamines - metabolism Urinary Bladder Neoplasms - metabolism Urinary Bladder Neoplasms - microbiology
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Zusammenfassung:	A recent Nature paper1 reveals that gut microbes metabolize N-butyl-N-(4-hydroxybutyl)-nitrosamine (BBN) into the bladder carcinogen N-n-butyl-N-(3-carboxypropyl)-nitrosamine (BCPN) in the intestines, establishing a direct link between gut microbial activity and the development of bladder cancer. A recent Nature paper reveals that gut microbes metabolize N-butyl-N-(4-hydroxybutyl)-nitrosamine (BBN) into the bladder carcinogen N-n-butyl-N-(3-carboxypropyl)-nitrosamine (BCPN) in the intestines, establishing a direct link between gut microbial activity and the development of bladder cancer.
ISSN:	1931-3128 1934-6069 1934-6069
DOI:	10.1016/j.chom.2024.09.003