Effects of capsaicin on esophageal peristalsis in humans using high resolution manometry

Background Capsaicin‐containing red pepper sauce suspension augments esophageal contraction amplitude on conventional manometry. This study used high‐resolution manometry (HRM) to investigate if capsaicin infusion modulates segmental esophageal smooth muscle peristalsis in healthy adults. Methods Sixteen healthy volunteers (mean age 37 years, 14 male) underwent HRM for the evaluation of primary peristalsis and secondary peristalsis using slow and rapid air distensions. Both primary and secondary peristalsis were assessed following infusions of capsaicin‐containing red pepper sauce and saline. Key Results Capsaicin infusion significantly increased heartburn symptoms compared to saline infusion (p