Reversible uncompetitive inhibition of metal-organic framework nanozymes: specific colorimetric assay of methidathion without enzymes

Reversible uncompetitive inhibition of metal-organic framework nanozymes: specific colorimetric assay of methidathion without enzymes

An Fe-based metal-organic framework (Fe-MOF) nanozyme with MIL-88B(Fe) structure was facilely prepared by an ultrasonic method. Its oxidase-like activity could be specifically inhibited by methidathion, which conformed to a reversible uncompetitive inhibition mechanism. Furthermore, a specific and e...

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Veröffentlicht in:Chemical communications (Cambridge, England) England), 2024-11, Vol.60 (92), p.13522-13525
Hauptverfasser: Chen, Haiying, Zhang, Xin, Gao, Weimin, Huang, Baojian, Han, Lei
Format: Artikel
Sprache:eng
Schlagworte:
Colorimetry
Iron
Metal-organic frameworks
Ultrasonic methods
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Zusammenfassung:An Fe-based metal-organic framework (Fe-MOF) nanozyme with MIL-88B(Fe) structure was facilely prepared by an ultrasonic method. Its oxidase-like activity could be specifically inhibited by methidathion, which conformed to a reversible uncompetitive inhibition mechanism. Furthermore, a specific and enzyme-free colorimetric assay of methidathion was established using Fe-MOF as the ideal recognition element.
ISSN:1359-7345
1364-548X
1364-548X
DOI:10.1039/d4cc04417g