Evaluation of Early Renal Changes in Type 2 Diabetes Mellitus Using Multiparametric MR Imaging
Purpose: To evaluate the clinical value of early renal changes in type 2 diabetes mellitus (T2DM) using multiparameter MRI.Methods: The study included 41 diabetics (normoalbuminuria: n = 23; microalbuminuria: n = 18) and 30 healthy controls. All subjects underwent intravoxel incoherent motion diffus...
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| description | Purpose: To evaluate the clinical value of early renal changes in type 2 diabetes mellitus (T2DM) using multiparameter MRI.Methods: The study included 41 diabetics (normoalbuminuria: n = 23; microalbuminuria: n = 18) and 30 healthy controls. All subjects underwent intravoxel incoherent motion diffusion-weighted imaging (IVIM), blood oxygen level dependent (BOLD) and arterial spin labeling (ASL) examinations. One-way analysis of variance was used to compare MRI parameters among the three groups. Pearson correlation analysis was used to evaluate the relationship between MRI parameters and estimated glomerular filtration rate (eGFR) and albumin–creatinine ratio (ACR). Receiver operating characteristic analysis was performed to assess the diagnostic performance.Results: There were statistical differences in cortical D, D*, f, renal blood flow (RBF) and medulla D, D*, f, R2* among the three groups (P |
| doi_str_mv | 10.2463/mrms.mp.2023-0148 |
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| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_3113747400</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>3113747400</sourcerecordid><originalsourceid>FETCH-LOGICAL-c355t-5e0ea810c70898fd39c176a5ac566336014ec0ea09a1e0fda37a94a72b2a23d53</originalsourceid><addsrcrecordid>eNpNkE1rGzEQhkVpyYeTH9BL0bGXdSXNfh6L67aBmEBIrhFj7ayjsNrdStqA_31lnJicNGied0Z6GPsqxVLlJfxw3oWlm5ZKKMiEzOtP7ELWtciUEuXnVENeZSBrdc4uQ3gRAurUPmPn0EAlVFNcsKf1K_YzRjsOfOz4Gn2_5_c0YM9XzzjsKHA78If9RFzxXxa3FNPVhvrexjnwx2CHHd_MfbQTenQUvTV8c89vHO5S64p96bAPdP12Ltjj7_XD6m92e_fnZvXzNjNQFDErSBDWUphK1E3dtdAYWZVYoCnKEqBMfyOTENGgJNG1CBU2OVZqq1BBW8CCfT_Onfz4b6YQtbPBpFfiQOMcNEgJVV7lScGCySNq_BiCp05P3jr0ey2FPmjVB63aTfqgVR-0psy3t_Hz1lF7Srx7TMDdEXgJEXd0AtBHa3o6jsT2NeW1eC8-rjiR5hm9pgH-AxAgkho</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>3113747400</pqid></control><display><type>article</type><title>Evaluation of Early Renal Changes in Type 2 Diabetes Mellitus Using Multiparametric MR Imaging</title><source>DOAJ Directory of Open Access Journals</source><source>Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals</source><source>PubMed Central Open Access</source><source>J-STAGE (Japan Science & Technology Information Aggregator, Electronic) Freely Available Titles - Japanese</source><source>PubMed Central</source><creator>Chen, Xinyi ; Ge, Chao ; Zhang, Yuling ; Ma, Yajie ; Li, Bei ; Chu, Zhiqiang ; Ji, Qian</creator><creatorcontrib>Chen, Xinyi ; Ge, Chao ; Zhang, Yuling ; Ma, Yajie ; Li, Bei ; Chu, Zhiqiang ; Ji, Qian</creatorcontrib><description>Purpose: To evaluate the clinical value of early renal changes in type 2 diabetes mellitus (T2DM) using multiparameter MRI.Methods: The study included 41 diabetics (normoalbuminuria: n = 23; microalbuminuria: n = 18) and 30 healthy controls. All subjects underwent intravoxel incoherent motion diffusion-weighted imaging (IVIM), blood oxygen level dependent (BOLD) and arterial spin labeling (ASL) examinations. One-way analysis of variance was used to compare MRI parameters among the three groups. Pearson correlation analysis was used to evaluate the relationship between MRI parameters and estimated glomerular filtration rate (eGFR) and albumin–creatinine ratio (ACR). Receiver operating characteristic analysis was performed to assess the diagnostic performance.Results: There were statistical differences in cortical D, D*, f, renal blood flow (RBF) and medulla D, D*, f, R2* among the three groups (P < 0.05). The cortical or medullary D, cortical f, and RBF were significantly positively correlated with eGFR (all P < 0.01). The cortical or medullary D, D*, f, cortical RBF were negatively correlated with ACR (all P < 0.05).To evaluate early kidney changes and degree of diabetes, cortical combined D and RBF (AUC [area under the curve] = 0.796 and 0.947, respectively) was better than single D or RBF (all P > 0.05); medullary combined D and R2* (AUC = 0.899 and 0.923, respectively) was better than single D or R2* (all P > 0.05), except single D (P = 0.005) in differentiating normoalbuminuria group from control group.Conclusion: The early changes of renal diffusion and perfusion, oxygenation level, and blood flow in T2DM could be evaluated noninvasively and quantitatively using IVIM, BOLD and ASL. Renal medullary combined IVIM-derived D and BOLD-derived R2* and cortical combined IVIM-derived D and ASL-derived RBF were better for evaluating early renal changes in T2DM.</description><identifier>ISSN: 1347-3182</identifier><identifier>ISSN: 1880-2206</identifier><identifier>EISSN: 1880-2206</identifier><identifier>DOI: 10.2463/mrms.mp.2023-0148</identifier><identifier>PMID: 39370295</identifier><language>eng</language><publisher>Japan: Japanese Society for Magnetic Resonance in Medicine</publisher><subject>arterial spin labeling ; blood oxygen level dependent ; diabetes ; diabetic kidney disease ; intravoxel incoherent motion</subject><ispartof>Magnetic Resonance in Medical Sciences, 2024, pp.mp.2023-0148</ispartof><rights>2024 by Japanese Society for Magnetic Resonance in Medicine</rights><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c355t-5e0ea810c70898fd39c176a5ac566336014ec0ea09a1e0fda37a94a72b2a23d53</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,860,1876,27903,27904</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/39370295$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Chen, Xinyi</creatorcontrib><creatorcontrib>Ge, Chao</creatorcontrib><creatorcontrib>Zhang, Yuling</creatorcontrib><creatorcontrib>Ma, Yajie</creatorcontrib><creatorcontrib>Li, Bei</creatorcontrib><creatorcontrib>Chu, Zhiqiang</creatorcontrib><creatorcontrib>Ji, Qian</creatorcontrib><title>Evaluation of Early Renal Changes in Type 2 Diabetes Mellitus Using Multiparametric MR Imaging</title><title>Magnetic Resonance in Medical Sciences</title><addtitle>MRMS</addtitle><description>Purpose: To evaluate the clinical value of early renal changes in type 2 diabetes mellitus (T2DM) using multiparameter MRI.Methods: The study included 41 diabetics (normoalbuminuria: n = 23; microalbuminuria: n = 18) and 30 healthy controls. All subjects underwent intravoxel incoherent motion diffusion-weighted imaging (IVIM), blood oxygen level dependent (BOLD) and arterial spin labeling (ASL) examinations. One-way analysis of variance was used to compare MRI parameters among the three groups. Pearson correlation analysis was used to evaluate the relationship between MRI parameters and estimated glomerular filtration rate (eGFR) and albumin–creatinine ratio (ACR). Receiver operating characteristic analysis was performed to assess the diagnostic performance.Results: There were statistical differences in cortical D, D*, f, renal blood flow (RBF) and medulla D, D*, f, R2* among the three groups (P < 0.05). The cortical or medullary D, cortical f, and RBF were significantly positively correlated with eGFR (all P < 0.01). The cortical or medullary D, D*, f, cortical RBF were negatively correlated with ACR (all P < 0.05).To evaluate early kidney changes and degree of diabetes, cortical combined D and RBF (AUC [area under the curve] = 0.796 and 0.947, respectively) was better than single D or RBF (all P > 0.05); medullary combined D and R2* (AUC = 0.899 and 0.923, respectively) was better than single D or R2* (all P > 0.05), except single D (P = 0.005) in differentiating normoalbuminuria group from control group.Conclusion: The early changes of renal diffusion and perfusion, oxygenation level, and blood flow in T2DM could be evaluated noninvasively and quantitatively using IVIM, BOLD and ASL. Renal medullary combined IVIM-derived D and BOLD-derived R2* and cortical combined IVIM-derived D and ASL-derived RBF were better for evaluating early renal changes in T2DM.</description><subject>arterial spin labeling</subject><subject>blood oxygen level dependent</subject><subject>diabetes</subject><subject>diabetic kidney disease</subject><subject>intravoxel incoherent motion</subject><issn>1347-3182</issn><issn>1880-2206</issn><issn>1880-2206</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2024</creationdate><recordtype>article</recordtype><recordid>eNpNkE1rGzEQhkVpyYeTH9BL0bGXdSXNfh6L67aBmEBIrhFj7ayjsNrdStqA_31lnJicNGied0Z6GPsqxVLlJfxw3oWlm5ZKKMiEzOtP7ELWtciUEuXnVENeZSBrdc4uQ3gRAurUPmPn0EAlVFNcsKf1K_YzRjsOfOz4Gn2_5_c0YM9XzzjsKHA78If9RFzxXxa3FNPVhvrexjnwx2CHHd_MfbQTenQUvTV8c89vHO5S64p96bAPdP12Ltjj7_XD6m92e_fnZvXzNjNQFDErSBDWUphK1E3dtdAYWZVYoCnKEqBMfyOTENGgJNG1CBU2OVZqq1BBW8CCfT_Onfz4b6YQtbPBpFfiQOMcNEgJVV7lScGCySNq_BiCp05P3jr0ey2FPmjVB63aTfqgVR-0psy3t_Hz1lF7Srx7TMDdEXgJEXd0AtBHa3o6jsT2NeW1eC8-rjiR5hm9pgH-AxAgkho</recordid><startdate>20241004</startdate><enddate>20241004</enddate><creator>Chen, Xinyi</creator><creator>Ge, Chao</creator><creator>Zhang, Yuling</creator><creator>Ma, Yajie</creator><creator>Li, Bei</creator><creator>Chu, Zhiqiang</creator><creator>Ji, Qian</creator><general>Japanese Society for Magnetic Resonance in Medicine</general><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20241004</creationdate><title>Evaluation of Early Renal Changes in Type 2 Diabetes Mellitus Using Multiparametric MR Imaging</title><author>Chen, Xinyi ; Ge, Chao ; Zhang, Yuling ; Ma, Yajie ; Li, Bei ; Chu, Zhiqiang ; Ji, Qian</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c355t-5e0ea810c70898fd39c176a5ac566336014ec0ea09a1e0fda37a94a72b2a23d53</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2024</creationdate><topic>arterial spin labeling</topic><topic>blood oxygen level dependent</topic><topic>diabetes</topic><topic>diabetic kidney disease</topic><topic>intravoxel incoherent motion</topic><toplevel>online_resources</toplevel><creatorcontrib>Chen, Xinyi</creatorcontrib><creatorcontrib>Ge, Chao</creatorcontrib><creatorcontrib>Zhang, Yuling</creatorcontrib><creatorcontrib>Ma, Yajie</creatorcontrib><creatorcontrib>Li, Bei</creatorcontrib><creatorcontrib>Chu, Zhiqiang</creatorcontrib><creatorcontrib>Ji, Qian</creatorcontrib><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Magnetic Resonance in Medical Sciences</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Chen, Xinyi</au><au>Ge, Chao</au><au>Zhang, Yuling</au><au>Ma, Yajie</au><au>Li, Bei</au><au>Chu, Zhiqiang</au><au>Ji, Qian</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Evaluation of Early Renal Changes in Type 2 Diabetes Mellitus Using Multiparametric MR Imaging</atitle><jtitle>Magnetic Resonance in Medical Sciences</jtitle><addtitle>MRMS</addtitle><date>2024-10-04</date><risdate>2024</risdate><spage>mp.2023-0148</spage><pages>mp.2023-0148-</pages><artnum>mp.2023-0148</artnum><issn>1347-3182</issn><issn>1880-2206</issn><eissn>1880-2206</eissn><abstract>Purpose: To evaluate the clinical value of early renal changes in type 2 diabetes mellitus (T2DM) using multiparameter MRI.Methods: The study included 41 diabetics (normoalbuminuria: n = 23; microalbuminuria: n = 18) and 30 healthy controls. All subjects underwent intravoxel incoherent motion diffusion-weighted imaging (IVIM), blood oxygen level dependent (BOLD) and arterial spin labeling (ASL) examinations. One-way analysis of variance was used to compare MRI parameters among the three groups. Pearson correlation analysis was used to evaluate the relationship between MRI parameters and estimated glomerular filtration rate (eGFR) and albumin–creatinine ratio (ACR). Receiver operating characteristic analysis was performed to assess the diagnostic performance.Results: There were statistical differences in cortical D, D*, f, renal blood flow (RBF) and medulla D, D*, f, R2* among the three groups (P < 0.05). The cortical or medullary D, cortical f, and RBF were significantly positively correlated with eGFR (all P < 0.01). The cortical or medullary D, D*, f, cortical RBF were negatively correlated with ACR (all P < 0.05).To evaluate early kidney changes and degree of diabetes, cortical combined D and RBF (AUC [area under the curve] = 0.796 and 0.947, respectively) was better than single D or RBF (all P > 0.05); medullary combined D and R2* (AUC = 0.899 and 0.923, respectively) was better than single D or R2* (all P > 0.05), except single D (P = 0.005) in differentiating normoalbuminuria group from control group.Conclusion: The early changes of renal diffusion and perfusion, oxygenation level, and blood flow in T2DM could be evaluated noninvasively and quantitatively using IVIM, BOLD and ASL. Renal medullary combined IVIM-derived D and BOLD-derived R2* and cortical combined IVIM-derived D and ASL-derived RBF were better for evaluating early renal changes in T2DM.</abstract><cop>Japan</cop><pub>Japanese Society for Magnetic Resonance in Medicine</pub><pmid>39370295</pmid><doi>10.2463/mrms.mp.2023-0148</doi><oa>free_for_read</oa></addata></record> |
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| source | DOAJ Directory of Open Access Journals; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; PubMed Central Open Access; J-STAGE (Japan Science & Technology Information Aggregator, Electronic) Freely Available Titles - Japanese; PubMed Central |
| subjects | arterial spin labeling blood oxygen level dependent diabetes diabetic kidney disease intravoxel incoherent motion |
| title | Evaluation of Early Renal Changes in Type 2 Diabetes Mellitus Using Multiparametric MR Imaging |
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