PRC2-RNA interactions: Viewpoint from Jimmy K. Guo, Mario R. Blanco, and Mitchell Guttman

Many reported PRC2-RNA interactions have been shown to be functionally dispensable, raising questions about whether they occur in vivo. Here, we lay out technical issues with existing evidence for direct binding and argue that there is currently a lack of biochemical or functional evidence for direct PRC2-RNA binding in vivo. Many reported PRC2-RNA interactions have been shown to be functionally dispensable, raising questions about whether they occur in vivo. Here, Guo et al. lay out technical issues with existing evidence for direct binding and argue that there is currently a lack of biochemical or functional evidence for direct PRC2-RNA binding in vivo.