A Mg Battery‐Integrated Bioelectronic Patch Provides Efficient Electrochemical Stimulations for Wound Healing

Bioelectronic patches hold promise for patient‐comfort wound healing providing simplified clinical operation. Currently, they face paramount challenges in establishing long‐term effective electronic interfaces with targeted cells and tissues due to the inconsistent energy output and high bio interface impedance. Here a new electrochemical stimulation technology is reported, using a simple wound patch, which integrates the efficient generation and delivery of stimulation. This is realized by employing a hydrogel bioelectronic interface as an active component in an integrated power source (i.e., Mg battery). The Mg battery enhances fibroblast functions (proliferation, migration, and growth factor secretion) and regulates macrophage phenotype (promoting regenerative polarization and down‐regulating pro‐inflammatory cytokines), by providing an electric field and the ability to control the cellular microenvironment through chemical release. This bioelectronic patch shows an effective and accelerated wound closure by guiding epithelial migration, mediating immune response, and promoting vasculogenesis. This new electrochemical‐mediated therapy may provide a new avenue for user‐friendly wound management as well as a platform for fundamental insights into cell stimulation. A bioelectronic patch composed of an Mg battery integrates capabilities of efficient generation and delivery of electro(chemical) stimulation. Cell culture with the battery offers the potential for elucidating the impact of electric field, ion flux, and chemical release on the structure/function of live cells and tissue. This work identifies new ways where electrochemistry could contribute to the field of bioelectronic medicine.