Balancing immune activation with Itk

Development of protective immune responses relies on a balance between proinflammatory CD4 T helper (Th) cell populations such as Th17 cells and regulatory CD4 T cells (Tregs) that keep immune activation in check. Evidence that interleukin-2–inducible T cell kinase (Itk) regulates this balance suppo...

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Veröffentlicht in:	Trends in pharmacological sciences (Regular ed.) 2024-11, Vol.45 (11), p.958-960
Hauptverfasser:	Kaul, Zenia, Schwartzberg, Pamela L.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Ca2+ signaling cytokines Humans Itk Protein-Tyrosine Kinases - metabolism T-Lymphocytes, Regulatory - immunology Th17 cells Th17 Cells - immunology Tregs
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Beschreibung
Zusammenfassung:	Development of protective immune responses relies on a balance between proinflammatory CD4 T helper (Th) cell populations such as Th17 cells and regulatory CD4 T cells (Tregs) that keep immune activation in check. Evidence that interleukin-2–inducible T cell kinase (Itk) regulates this balance supports therapeutic applications for Itk inhibition. Development of protective immune responses relies on a balance between proinflammatory CD4 T helper (Th) cell populations such as Th17 cells and regulatory CD4 T cells (Tregs) that keep immune activation in check. Evidence that interleukin-2–inducible T cell kinase (Itk) regulates this balance supports therapeutic applications for Itk inhibition.
ISSN:	0165-6147 1873-3735 1873-3735
DOI:	10.1016/j.tips.2024.09.005