Relationship between HLA-II Gene Polymorphisms and Immune Response in COVID-19 Survivors and Volunteers Vaccinated against This Infection

The polymorphism of HLA class II genes was studied in COVID-19 survivors and vaccinated people. Six allelic variants of DQA1 , 10 of DQB1 , and 11 of DRB1 were identified. The DQA1 * 05:01 allele predominated in vaccinated volunteers and the DQA1 * 02:01 , * 01:03 , and DQB1 * 06:02-8 alleles predom...

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Veröffentlicht in:Bulletin of experimental biology and medicine 2024-09, Vol.177 (5), p.653-657
Hauptverfasser: Dubrovina, V. I., Bryukhova, D. D., Korytov, K. M., Pyatidesyatnikova, A. B., Vishnyakov, V. A., Balakhonov, S. V.
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Sprache:eng
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Zusammenfassung:The polymorphism of HLA class II genes was studied in COVID-19 survivors and vaccinated people. Six allelic variants of DQA1 , 10 of DQB1 , and 11 of DRB1 were identified. The DQA1 * 05:01 allele predominated in vaccinated volunteers and the DQA1 * 02:01 , * 01:03 , and DQB1 * 06:02-8 alleles predominated in convalescents. In the groups with DQA1 * 01:01 , * 05:01 and * 06:01 alleles, a high proportion of individuals seropositive for SARS-CoV-2 S protein was found. In the group with DQA1 * 02:01 allele, 40% of volunteers were found to have IgM and a significantly lower quantity of IgG to N protein of coronavirus. Comparative analysis showed a statistically significant increase in IL-10 levels in carriers of the DQA1 * 01:01 allele, which may indicate the influence of this allele on cytokine production. Further study of the immune response indices and their association with HLA class II gene polymorphism will provide better understanding of the mechanisms of COVID-19 immunogenesis.
ISSN:0007-4888
1573-8221
1573-8221
DOI:10.1007/s10517-024-06243-4