Comparative Study of the Anxiolytic Activity of Songorine in Elevated Plus Maze Test and by Recording Ultrasonic Vocalizations

It was found that the diterpene alkaloid songorine administered per os to mice at a dose of 25 μg/kg provides a pronounced anxiolytic effect during elevated plus maze testing comparable to the effect of the benzodiazepine anxiolytic phenazepam. Recording of ultrasonic vocalizations of animals reveal...

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Veröffentlicht in:	Bulletin of experimental biology and medicine 2024-09, Vol.177 (5), p.648-652
Hauptverfasser:	Nesterova, Yu. V., Vsyakikh, O. V., Kul’pin, P. V., Povetyeva, T. N., Zyuz’kov, G. N., Suslov, N. I., Zhdanov, V. V., Losev, E. A.
Format:	Artikel
Sprache:	eng
Schlagworte:	Acoustics Alkaloids Animals Anti-Anxiety Agents - pharmacology Anxiety - drug therapy Behavior Behavior, Animal - drug effects Benzodiazepines Benzodiazepines - pharmacology Biomedical and Life Sciences Biomedicine Cell Biology Diterpenes - pharmacology Drug dosages Elevated Plus Maze Test Internal Medicine Laboratory Medicine Male Maze Learning - drug effects Mice Pathology Pharmacology Regenerative medicine Research centers Software Toxicology Ultrasonics Vocalization, Animal - drug effects
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Zusammenfassung:	It was found that the diterpene alkaloid songorine administered per os to mice at a dose of 25 μg/kg provides a pronounced anxiolytic effect during elevated plus maze testing comparable to the effect of the benzodiazepine anxiolytic phenazepam. Recording of ultrasonic vocalizations of animals revealed an increase in the number of short high-frequency (50 kHz) signals under the action of songorine and the reference drug, which confirms their anti-anxiety properties.
ISSN:	0007-4888 1573-8221 1573-8221
DOI:	10.1007/s10517-024-06242-5