Muti-target rationale design of novel substituted N-phenyl-2-((6-phenylpyridazin-3-yl)thio)acetamide candidates as telomerase/JAK1/STAT3/TLR4 inhibitors: In vitro and in vivo investigations

[Display omitted] •The new candidate 4l with improved telomerase and growth inhibition suggesting its potential use as a successful “multitarget-directed drug”.•Compound 4l was further selected to evaluate its additional JAK1/STAT3/TLR4 inhibitory potentials.•Compound 4l represented a very promising...

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Veröffentlicht in:Bioorganic chemistry 2024-12, Vol.153, p.107843, Article 107843
Hauptverfasser: Shaldam, Moataz A., Mousa, Mai H.A., Tawfik, Haytham O., El-Dessouki, Ahmed M., Sharaky, Marwa, Saleh, Mohamed M., Alzahrani, Abdullah Yahya Abdullah, Moussa, Sana Ben, Al-Karmalawy, Ahmed A.
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Sprache:eng
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