Muti-target rationale design of novel substituted N-phenyl-2-((6-phenylpyridazin-3-yl)thio)acetamide candidates as telomerase/JAK1/STAT3/TLR4 inhibitors: In vitro and in vivo investigations
[Display omitted] •The new candidate 4l with improved telomerase and growth inhibition suggesting its potential use as a successful “multitarget-directed drug”.•Compound 4l was further selected to evaluate its additional JAK1/STAT3/TLR4 inhibitory potentials.•Compound 4l represented a very promising...
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Veröffentlicht in: | Bioorganic chemistry 2024-12, Vol.153, p.107843, Article 107843 |
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Hauptverfasser: | , , , , , , , , |
Format: | Artikel |
Sprache: | eng |
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