Long‐term risk of mortality and loss to follow‐up in children and adolescents on antiretroviral therapy in Asia

Objective We described mortality and loss to follow‐up (LTFU) in children and adolescents who were under care for more than 5 years following initiation of antiretroviral therapy (ART). Methods Patients were followed from 5 years after ART until the earlier of their 25th birthday, last visit, death,...

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Veröffentlicht in:	HIV medicine 2025-01, Vol.26 (1), p.140-152
Hauptverfasser:	Nimkar, Smita, Kinikar, Aarti, Mave, Vidya, Khol, Vohith, Du, Quy Tuan, Nguyen, Lam, Ounchanum, Pradthana, Nguyen, Dinh Qui, Puthanakit, Thanyawee, Kosalaraks, Pope, Chokephaibulkit, Kulkanya, Sudjaritruk, Tavitiya, Muktiarti, Dina, Kumarasamy, Nagalingeswaran, Yusoff, Nik Khairulddin Nik, Mohamed, Thahira, Wati, Dewi, Alam, Anggraini, Fong, Siew, Nallusamy, Revathy, Suwanlerk, Tulathip, Sohn, Annette, Kariminia, Azar, Ly, PS, Khol, V, Penh, Phnom, Tucker, J, Kumarasamy, N, Chandrasekaran, E, Kinikar, A, Mave, V, Nimkar, S, Marbaniang, I, Wati, DK, Vedaswari, D, Ramajaya, IB, Ngoerah, I.G.N.G., Kurniati, N, Muktiarti, D, Mangunkusumo, Cipto, Fong, SM, Lim, M, Daut, F, Yusoff, NK Nik, Mohamad, P, Mohamed, TJ, Drawis, MR, Nallusamy, R, Chan, KC, Sudjaritruk, T, Sirisanthana, V, Aurpibul, L, Ounchanum, P, Hansudewechakul, R, Denjanta, S, Kongphonoi, A, Lumbiganon, P, Kosalaraksa, P, Tharnprisan, P, Udomphanit, T, Jourdain, G, Puthanakit, T, Anugulruengkit, S, Jantarabenjakul, W, Nadsasarn, R, Chokephaibulkit, K, Lapphra, K, Phongsamart, W, Sricharoenchai, S, Truong, KH, Du, QT, Nguyen, CH, Nguyen, LV, Tran, DM, Tran, HTT, Giang, TTT, Le, ON, Sohn, AH, Ross, JL, Suwanlerk, T, Law, MG, Kariminia, A
Format:	Artikel
Sprache:	eng
Schlagworte:	Adolescent Adolescents Anti-HIV Agents - therapeutic use Anti-Retroviral Agents - therapeutic use Antiretroviral agents Antiretroviral therapy Asia - epidemiology CD4 antigen CD4 Lymphocyte Count Child Child, Preschool Children Children & youth Drug therapy Female Follow-Up Studies HIV Infections - drug therapy HIV Infections - mortality HIV‐infected children and adolescents Humans Infant long‐term ART loss to follow‐up Lost to Follow-Up Male Mortality Mortality risk Proportional Hazards Models Risk Factors Sex ratio Statistical analysis Teenagers Viral Load
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Zusammenfassung:	Objective We described mortality and loss to follow‐up (LTFU) in children and adolescents who were under care for more than 5 years following initiation of antiretroviral therapy (ART). Methods Patients were followed from 5 years after ART until the earlier of their 25th birthday, last visit, death, or LTFU. We used Cox regression to assess predictors of mortality and competing risk regression to assess factors associated with LTFU. Results In total, 4488 children and adolescents initiating ART between 1997 and 2016 were included in the analysis, with a median follow‐up time of 5.2 years. Of these, 107 (2.2%) died and 271 (6.0%) were LTFU. Mortality rate was 4.35 and LTFU rate 11.01 per 1000 person‐years. Increased mortality was associated with AIDS diagnosis (adjusted hazard ratio [aHR] 1.71; 95% confidence interval [CI] 1.24–2.37), current CD4 count
ISSN:	1464-2662 1468-1293 1468-1293
DOI:	10.1111/hiv.13718