Exercise intolerance and oxygen dynamics in nontuberculous mycobacteria with bronchiectasis
Nontuberculous mycobacterial pulmonary disease (NTM-PD) patients often have exercise intolerance. Pulmonary rehabilitation (PR) to improve such patients' conditions is often not based on its exercise pathophysiology. We have reported that the oxygen consumption (ΔFO2) by expiratory gas analysis...
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| Veröffentlicht in: | Respiratory investigation 2024-11, Vol.62 (6), p.1058-1063 |
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| creator | Miyamoto, Satoshi Miki, Keisuke Kitada, Seigo Nagata, Yuka Kijima, Ryo Mihashi, Yasuhiro Hashimoto, Hisako Maekura, Tomonori Yonezawa, Rika Sakaguchi, Shizuka Yanagi, Hiromi Koyama, Kazumi Nii, Takuro Matsuki, Takanori Tsujino, Kazuyuki Kida, Hiroshi |
| description | Nontuberculous mycobacterial pulmonary disease (NTM-PD) patients often have exercise intolerance. Pulmonary rehabilitation (PR) to improve such patients' conditions is often not based on its exercise pathophysiology. We have reported that the oxygen consumption (ΔFO2) by expiratory gas analysis, i.e., the inspired-expired-expiratory mean oxygen concentration difference, is related to the minute ventilation-carbon dioxide output (V′E-V′CO2)-slope and oxygen uptake (V′O2) independent of the V′E. The aim of this study was to investigate how ΔFO2 is related to dynamic ventilatory variables, chest computed tomography (CT), and echocardiography findings in NTM-PD patients to understand their pathophysiological conditions.
Clinical data of NTM-PD patients with exertional dyspnea (n = 29) who underwent incremental exercise testing, chest CT, and echocardiography at the same time were compared with those of control participants (n = 12).
In the NTM-PD group, 1) peak V′O2 decreased (NTM-PD: 17.6 vs. controls: 28.7 mL⋅min−1⋅kg−1), and 2) ΔFO2 at peak exercise was negatively correlated with respiratory frequency at peak exercise (correlation coefficient: r = −0.80, p |
| doi_str_mv | 10.1016/j.resinv.2024.08.017 |
| format | Article |
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Clinical data of NTM-PD patients with exertional dyspnea (n = 29) who underwent incremental exercise testing, chest CT, and echocardiography at the same time were compared with those of control participants (n = 12).
In the NTM-PD group, 1) peak V′O2 decreased (NTM-PD: 17.6 vs. controls: 28.7 mL⋅min−1⋅kg−1), and 2) ΔFO2 at peak exercise was negatively correlated with respiratory frequency at peak exercise (correlation coefficient: r = −0.80, p < 0.0001), V′E-V′CO2-slope (r = −0.75, p < 0.0001), bronchiectasis CT score (r = −0.52, p = 0.0042), and the trans-tricuspid pressure gradient (r = −0.39, p = 0.0417), and positively correlated with peak V'O2 (r = 0.71, p < 0.0001) and the body mass index (r = 0.42, p = 0.0217), but it was not correlated with V′E at peak exercise and the cavity CT score.
Exertional oxygen consumption, independent of ventilatory ability, is associated with exercise tolerance and ventilatory efficiency, while being related to tachypnea and bronchiectasis rather than cavitation in NTM-PD patients. These findings may be useful in considering exercise physiology-based PR for NTM-PD patients with exertional dyspnea.</description><identifier>ISSN: 2212-5345</identifier><identifier>ISSN: 2212-5353</identifier><identifier>EISSN: 2212-5353</identifier><identifier>DOI: 10.1016/j.resinv.2024.08.017</identifier><identifier>PMID: 39305533</identifier><language>eng</language><publisher>Netherlands: Elsevier B.V</publisher><subject>Aged ; And ventilation ; Bronchiectasis - physiopathology ; Cardiopulmonary exercise testing ; Dyspnea ; Echocardiography ; Exercise Test ; Exercise Tolerance ; Female ; Humans ; Male ; Middle Aged ; Mycobacterium Infections, Nontuberculous - physiopathology ; Nontuberculous Mycobacteria ; Oxygen - metabolism ; Oxygen Consumption ; Pulmonary rehabilitation ; Tachypnea ; Tomography, X-Ray Computed</subject><ispartof>Respiratory investigation, 2024-11, Vol.62 (6), p.1058-1063</ispartof><rights>2024 The Japanese Respiratory Society</rights><rights>Copyright © 2024 The Japanese Respiratory Society. Published by Elsevier B.V. All rights reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c241t-32a0b1dceed82fc9b09560d49e69288520f9b834205a1e0ee259e25a6f8b78873</cites><orcidid>0000-0002-4416-6083</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,27901,27902</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/39305533$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Miyamoto, Satoshi</creatorcontrib><creatorcontrib>Miki, Keisuke</creatorcontrib><creatorcontrib>Kitada, Seigo</creatorcontrib><creatorcontrib>Nagata, Yuka</creatorcontrib><creatorcontrib>Kijima, Ryo</creatorcontrib><creatorcontrib>Mihashi, Yasuhiro</creatorcontrib><creatorcontrib>Hashimoto, Hisako</creatorcontrib><creatorcontrib>Maekura, Tomonori</creatorcontrib><creatorcontrib>Yonezawa, Rika</creatorcontrib><creatorcontrib>Sakaguchi, Shizuka</creatorcontrib><creatorcontrib>Yanagi, Hiromi</creatorcontrib><creatorcontrib>Koyama, Kazumi</creatorcontrib><creatorcontrib>Nii, Takuro</creatorcontrib><creatorcontrib>Matsuki, Takanori</creatorcontrib><creatorcontrib>Tsujino, Kazuyuki</creatorcontrib><creatorcontrib>Kida, Hiroshi</creatorcontrib><title>Exercise intolerance and oxygen dynamics in nontuberculous mycobacteria with bronchiectasis</title><title>Respiratory investigation</title><addtitle>Respir Investig</addtitle><description>Nontuberculous mycobacterial pulmonary disease (NTM-PD) patients often have exercise intolerance. Pulmonary rehabilitation (PR) to improve such patients' conditions is often not based on its exercise pathophysiology. We have reported that the oxygen consumption (ΔFO2) by expiratory gas analysis, i.e., the inspired-expired-expiratory mean oxygen concentration difference, is related to the minute ventilation-carbon dioxide output (V′E-V′CO2)-slope and oxygen uptake (V′O2) independent of the V′E. The aim of this study was to investigate how ΔFO2 is related to dynamic ventilatory variables, chest computed tomography (CT), and echocardiography findings in NTM-PD patients to understand their pathophysiological conditions.
Clinical data of NTM-PD patients with exertional dyspnea (n = 29) who underwent incremental exercise testing, chest CT, and echocardiography at the same time were compared with those of control participants (n = 12).
In the NTM-PD group, 1) peak V′O2 decreased (NTM-PD: 17.6 vs. controls: 28.7 mL⋅min−1⋅kg−1), and 2) ΔFO2 at peak exercise was negatively correlated with respiratory frequency at peak exercise (correlation coefficient: r = −0.80, p < 0.0001), V′E-V′CO2-slope (r = −0.75, p < 0.0001), bronchiectasis CT score (r = −0.52, p = 0.0042), and the trans-tricuspid pressure gradient (r = −0.39, p = 0.0417), and positively correlated with peak V'O2 (r = 0.71, p < 0.0001) and the body mass index (r = 0.42, p = 0.0217), but it was not correlated with V′E at peak exercise and the cavity CT score.
Exertional oxygen consumption, independent of ventilatory ability, is associated with exercise tolerance and ventilatory efficiency, while being related to tachypnea and bronchiectasis rather than cavitation in NTM-PD patients. These findings may be useful in considering exercise physiology-based PR for NTM-PD patients with exertional dyspnea.</description><subject>Aged</subject><subject>And ventilation</subject><subject>Bronchiectasis - physiopathology</subject><subject>Cardiopulmonary exercise testing</subject><subject>Dyspnea</subject><subject>Echocardiography</subject><subject>Exercise Test</subject><subject>Exercise Tolerance</subject><subject>Female</subject><subject>Humans</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Mycobacterium Infections, Nontuberculous - physiopathology</subject><subject>Nontuberculous Mycobacteria</subject><subject>Oxygen - metabolism</subject><subject>Oxygen Consumption</subject><subject>Pulmonary rehabilitation</subject><subject>Tachypnea</subject><subject>Tomography, X-Ray Computed</subject><issn>2212-5345</issn><issn>2212-5353</issn><issn>2212-5353</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2024</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kEtLxDAQgIMoKqv_QKRHL1snSdOmF0HEFyx40ZOHkKZTzdIma9Lq7r83srpHA0MC880jHyFnFHIKtLxc5gGjdZ85A1bkIHOg1R45ZoyyueCC7-_ehTgipzEuIZ1SsIKWh-SI1xyE4PyYvN6uMRgbMbNu9D0G7Qxm2rWZX2_e0GXtxunBmpjymfNunJrET72fYjZsjG-0GTFYnX3Z8T1rgnfm3aIZdbTxhBx0uo94-nvPyMvd7fPNw3zxdP94c72Ym7TOOOdMQ0Nbg9hK1pm6gVqU0BY1ljWTUjDo6kbygoHQFAGRiTqFLjvZVFJWfEYutn1XwX9MGEc12Giw77XDtKfiFKpKihpEQostaoKPMWCnVsEOOmwUBfVjVi3V1qz6MatAqmQ2lZ3_TpiaAdtd0Z_HBFxtAUz__LQYVDQWk8rWhmRDtd7-P-Eb7ECNOw</recordid><startdate>202411</startdate><enddate>202411</enddate><creator>Miyamoto, Satoshi</creator><creator>Miki, Keisuke</creator><creator>Kitada, Seigo</creator><creator>Nagata, Yuka</creator><creator>Kijima, Ryo</creator><creator>Mihashi, Yasuhiro</creator><creator>Hashimoto, Hisako</creator><creator>Maekura, Tomonori</creator><creator>Yonezawa, Rika</creator><creator>Sakaguchi, Shizuka</creator><creator>Yanagi, Hiromi</creator><creator>Koyama, Kazumi</creator><creator>Nii, Takuro</creator><creator>Matsuki, Takanori</creator><creator>Tsujino, Kazuyuki</creator><creator>Kida, Hiroshi</creator><general>Elsevier B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0002-4416-6083</orcidid></search><sort><creationdate>202411</creationdate><title>Exercise intolerance and oxygen dynamics in nontuberculous mycobacteria with bronchiectasis</title><author>Miyamoto, Satoshi ; 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Pulmonary rehabilitation (PR) to improve such patients' conditions is often not based on its exercise pathophysiology. We have reported that the oxygen consumption (ΔFO2) by expiratory gas analysis, i.e., the inspired-expired-expiratory mean oxygen concentration difference, is related to the minute ventilation-carbon dioxide output (V′E-V′CO2)-slope and oxygen uptake (V′O2) independent of the V′E. The aim of this study was to investigate how ΔFO2 is related to dynamic ventilatory variables, chest computed tomography (CT), and echocardiography findings in NTM-PD patients to understand their pathophysiological conditions.
Clinical data of NTM-PD patients with exertional dyspnea (n = 29) who underwent incremental exercise testing, chest CT, and echocardiography at the same time were compared with those of control participants (n = 12).
In the NTM-PD group, 1) peak V′O2 decreased (NTM-PD: 17.6 vs. controls: 28.7 mL⋅min−1⋅kg−1), and 2) ΔFO2 at peak exercise was negatively correlated with respiratory frequency at peak exercise (correlation coefficient: r = −0.80, p < 0.0001), V′E-V′CO2-slope (r = −0.75, p < 0.0001), bronchiectasis CT score (r = −0.52, p = 0.0042), and the trans-tricuspid pressure gradient (r = −0.39, p = 0.0417), and positively correlated with peak V'O2 (r = 0.71, p < 0.0001) and the body mass index (r = 0.42, p = 0.0217), but it was not correlated with V′E at peak exercise and the cavity CT score.
Exertional oxygen consumption, independent of ventilatory ability, is associated with exercise tolerance and ventilatory efficiency, while being related to tachypnea and bronchiectasis rather than cavitation in NTM-PD patients. These findings may be useful in considering exercise physiology-based PR for NTM-PD patients with exertional dyspnea.</abstract><cop>Netherlands</cop><pub>Elsevier B.V</pub><pmid>39305533</pmid><doi>10.1016/j.resinv.2024.08.017</doi><tpages>6</tpages><orcidid>https://orcid.org/0000-0002-4416-6083</orcidid></addata></record> |
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| subjects | Aged And ventilation Bronchiectasis - physiopathology Cardiopulmonary exercise testing Dyspnea Echocardiography Exercise Test Exercise Tolerance Female Humans Male Middle Aged Mycobacterium Infections, Nontuberculous - physiopathology Nontuberculous Mycobacteria Oxygen - metabolism Oxygen Consumption Pulmonary rehabilitation Tachypnea Tomography, X-Ray Computed |
| title | Exercise intolerance and oxygen dynamics in nontuberculous mycobacteria with bronchiectasis |
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