Exercise intolerance and oxygen dynamics in nontuberculous mycobacteria with bronchiectasis

Nontuberculous mycobacterial pulmonary disease (NTM-PD) patients often have exercise intolerance. Pulmonary rehabilitation (PR) to improve such patients' conditions is often not based on its exercise pathophysiology. We have reported that the oxygen consumption (ΔFO2) by expiratory gas analysis, i.e., the inspired-expired-expiratory mean oxygen concentration difference, is related to the minute ventilation-carbon dioxide output (V′E-V′CO2)-slope and oxygen uptake (V′O2) independent of the V′E. The aim of this study was to investigate how ΔFO2 is related to dynamic ventilatory variables, chest computed tomography (CT), and echocardiography findings in NTM-PD patients to understand their pathophysiological conditions. Clinical data of NTM-PD patients with exertional dyspnea (n = 29) who underwent incremental exercise testing, chest CT, and echocardiography at the same time were compared with those of control participants (n = 12). In the NTM-PD group, 1) peak V′O2 decreased (NTM-PD: 17.6 vs. controls: 28.7 mL⋅min−1⋅kg−1), and 2) ΔFO2 at peak exercise was negatively correlated with respiratory frequency at peak exercise (correlation coefficient: r = −0.80, p