Disruption of the Circulating Proteome in Neonates Receiving Extracorporeal Membrane Oxygenation Following Congenital Heart Disease Surgery: A Nested Case-Control Study

This nested case-control study identified broad dysregulation of the circulating proteome in neonates receiving postoperative extracorporeal membrane oxygenation support after congenital heart disease surgery, including differential responses in those not surviving to hospital discharge. Tissue hypo...

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Veröffentlicht in:	The Journal of pediatrics 2025-01, Vol.276, p.114322, Article 114322
Hauptverfasser:	Thomson, Lindsay M., Niemiec, Sierra, Mancuso, Christopher A., Khailova, Ludmila, Ali, Eiman, Syed, Aneesa, Wolfe, Kelly R., Zakrzewski, Jack, Stone, Matthew, Hyslop, Robert, Frank, Benjamin S., Davidson, Jesse A.
Format:	Artikel
Sprache:	eng
Schlagworte:	Biomarkers - blood cardiac surgery Cardiac Surgical Procedures cardiopulmonary bypass Case-Control Studies ECMO erythropoietin Extracorporeal Membrane Oxygenation Female Heart Defects, Congenital - blood Heart Defects, Congenital - surgery Humans Infant, Newborn Male protein biomarkers Proteome proteomics
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Zusammenfassung:	This nested case-control study identified broad dysregulation of the circulating proteome in neonates receiving postoperative extracorporeal membrane oxygenation support after congenital heart disease surgery, including differential responses in those not surviving to hospital discharge. Tissue hypoxia and mitochondrial-associated proteins may represent novel candidate biomarkers for poor extracorporeal membrane oxygenation outcomes.
ISSN:	0022-3476 1097-6833 1097-6833
DOI:	10.1016/j.jpeds.2024.114322