Clinical and proteomic profiles of chronic kidney disease in heart failure with reduced and preserved ejection fraction

Clinical and proteomic profiles of chronic kidney disease in heart failure with reduced and preserved ejection fraction

Chronic kidney disease (CKD) is prevalent and related to poor clinical outcomes in patients with heart failure (HF). The pathophysiology of CKD in HF with a reduced ejection fraction (HFrEF) and HF with a preserved ejection fraction (HFpEF) is not well defined. In this study we compared clinical and...

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Veröffentlicht in:International journal of cardiology 2024-12, Vol.417, p.132580, Article 132580
Hauptverfasser: Voordes, Geert H.D., Voors, Adriaan A., Hoegl, Annabelle, Madsen, Christian T., van Essen, Bart J., Ouwerkerk, Wouter, Tromp, Jasper, de la Rambelje, Mark A., Grønborg, Mads, Refsgaard, Jan C., Lang, Chim C., Barascuk-Michaelsen, Natasha, Damman, Kevin
Format: Artikel
Sprache:eng
Schlagworte:
CKD
Heart Failure
HFpEF
HFrEF
Proteomics
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Zusammenfassung:Chronic kidney disease (CKD) is prevalent and related to poor clinical outcomes in patients with heart failure (HF). The pathophysiology of CKD in HF with a reduced ejection fraction (HFrEF) and HF with a preserved ejection fraction (HFpEF) is not well defined. In this study we compared clinical and proteomic profiles of CKD between patients with HFrEF and HFpEF. We included 478 patients of the Scottish BIOSTAT-CHF cohort, of which 246 had HFrEF and 232 had HFpEF. CKD was defined as an eGFR
ISSN:0167-5273
1874-1754
1874-1754
DOI:10.1016/j.ijcard.2024.132580