Antibiotic resistance genes (ARGs) and their eco-environmental response in the Bohai Sea sediments

Antibiotic resistance genes (ARGs) are an important class of pollutants in the environment. This study investigated the characteristics and ecological effects of ARGs in the Bohai Sea sediments. The results showed that ARGs are widely distributed, and exhibit significant spatial and subtype variations, with absolute abundance following the decreasing order of Liaodong Bay, Laizhou Bay, Bohai Bay, and Bohai Strait. Tetracycline ARGs dominated, comprising 50 % to 62 % of all ARGs, with tetM having the highest abundance at 1.43 × 107 copies/g. Symbiotic network analysis revealed that the phyla Deinococcota, Dadabacteria were serve as the primary likely host of ARGs. The ARGs have a wide range of potential hosts, and bacteria often carry multiple ARGs, enhancing the mobility and ecological niche adaptation of ARGs. This study will provide an important reference for assessing ARGs pollution in semi-enclosed seas. [Display omitted] •ARGs exhibited significant spatial and subtype variations.•TOC and TN significantly influenced 16S rRNA abundance and promoted ARG occurrence and dissemination.•Sediment grain size and silt content affected ARGs by influencing intI1 abundance.•ARGs have a wide range of potential hosts and have a good mobility and ecological niche adaptation.