Anthropometry relationship with duodenal histologic features of children with environmental enteric dysfunction: a multicenter cross-sectional study

Environmental enteric dysfunction (EED) is a precursor of growth faltering in children living in impoverished conditions who are frequently exposed to environmental toxins and enteropathogens, leading to small bowel inflammatory, malabsorptive, and permeability derangements and low-grade chronic sys...

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Veröffentlicht in:	The American journal of clinical nutrition 2024-09, Vol.120, p.S65-S72
Hauptverfasser:	Jamil, Zehra, VanBuskirk, Kelley, Mweetwa, Monica, Mouksassi, Samer, Smith, Gerald, Ahmed, Tahmeed, Chandwe, Kanta, Denno, Donna M, Fahim, S Mohammad, Kelly, Paul, Mahfuz, Mustafa, Mallawaarachchi, Indika, Marie, Chelsea, Moore, Sean R, Petri, William A, Ali, S Asad, Ahmed, Kumail, Ahmed, Sheraz, Alam, Md. Ashraful, Amadi, Beatrice, Banda, Rosemary, Dars, Shareef, Das, Subhasish, Denson, Lee A., Hossain, Md. Shabab, Hotwani, Aneeta, Iqbal, Junaid, Iqbal, Najeeha Talat, Jakhro, Sadaf, Kabir, Furqan, Kazhila, Lydia, Liu, Ta-Chiang, Mann, Barbara J., Memon, Waheeda, Moskaluk, Christopher A, Qureshi, Abdul Khalique, Ragahavan, Shyam S, Rahman, Masudur, Rahman, Najeeb, Sadiq, Kamran, Sarker, Shafiqul Alam, Sullivan, Peter B., Tarr, Phillip I., Tearney, Guillermo J., Umrani, Fayaz, Yilmaz, Omer H.
Format:	Artikel
Sprache:	eng
Schlagworte:	Anthropometry Bangladesh Body height Child Child, Preschool Children Confidence intervals Cross-Sectional Studies Depletion duodenal histology Duodenum - pathology Endoscopy environmental enteric dysfunction Female Growth Disorders - etiology Heat affected zone Histology Humans Infant Male Pakistan Pattern analysis Phenotypes Regression analysis Regression models Small intestine Statistical analysis Statistical models Structural members Structure-function relationships stunting Toxins wasting Zambia
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Zusammenfassung:	Environmental enteric dysfunction (EED) is a precursor of growth faltering in children living in impoverished conditions who are frequently exposed to environmental toxins and enteropathogens, leading to small bowel inflammatory, malabsorptive, and permeability derangements and low-grade chronic systemic inflammation. We explored the association between anthropometrics and duodenal histologic features of EED among children from 3 lower middle-income country centers. In this cross-sectional study, Pakistani children (n = 63) with wasting, Bangladesh children (n = 116) with stunting or at risk for stunting (height-for-age Z score [HAZ]
ISSN:	0002-9165 1938-3207 1938-3207
DOI:	10.1016/j.ajcnut.2024.02.027