Beyond Immunity: Challenges in Kidney Retransplantation Among Persons Living With HIV

While superb outcomes have been observed in the HIV-positive (HIV+) population, graft failure and subsequent need for kidney retransplantation (re-KT) remain a concern. This study aims to investigate the difference in success rates of re-KT allograft survival in the HIV+ versus HIV-negative (HIV−) population in the current era of transplantation (2014-2022). Data was collected from the Organ Procurement and Transplantation Network on all kidney transplant donors and recipients who had their first re-KT between 2014 and 2022. Allograft survival was assessed using Kaplan–Meier analysis with a log-rank test, while risk factors for graft loss were assessed using Cox proportional hazards with statistical significance set to P = 0.05. HIV+ recipients were significantly more likely to be Black (P 3 (P = 0.018), delayed graft function (P = 0.023), and graft loss from primary nonfunction (P