Retinal electrophysiological alterations are associated with cognition in early course psychosis
Retinal electrophysiological alterations are implicated in psychosis, but their relationship with cognition in early course psychosis (ECP) is understudied. The Brief Assessment of Cognition (BAC) and flash electroretinography (fERG) were conducted in 24 controls (HC) and 27 ECP individuals. Partial...
Gespeichert in:
| Veröffentlicht in: | Schizophrenia research 2024-12, Vol.274, p.137-141 |
|---|---|
| Hauptverfasser: | , , , , , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 141 |
|---|---|
| container_issue | |
| container_start_page | 137 |
| container_title | Schizophrenia research |
| container_volume | 274 |
| creator | Molho, Willa Stiltner, Brendan Raymond, Nicolas Kiely, Chelsea Trotti, Rebekah Harris, Caroline Bannai, Deepthi Keshavan, Matcheri Silverstein, Steven Lizano, Paulo |
| description | Retinal electrophysiological alterations are implicated in psychosis, but their relationship with cognition in early course psychosis (ECP) is understudied. The Brief Assessment of Cognition (BAC) and flash electroretinography (fERG) were conducted in 24 controls (HC) and 27 ECP individuals. Partial Spearman correlations were performed between fERG and BAC. Lower Photopic-1b and Scotopic-3b amplitudes were identified in ECP vs. HCs. Correlations were significant (p |
| doi_str_mv | 10.1016/j.schres.2024.09.013 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_3106733233</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><els_id>S0920996424004195</els_id><sourcerecordid>3106733233</sourcerecordid><originalsourceid>FETCH-LOGICAL-c241t-8326f3b42eee6bb39deda568ceaa6a97c4c72f95ad9ba65ab95c22eeea78987c3</originalsourceid><addsrcrecordid>eNp9kE1LAzEQhoMotlb_gcgeveyaj_1oLoIUv6AgiJ7jbHbapmw3NbNV-u9NafXoaeCdZ2aYh7FLwTPBRXmzzMguAlImucwzrjMu1BEbiqJSqSy4PmZDriVPtS7zATsjWnLORcGrUzZQWmolCzFkH6_Yuw7aBFu0ffDrxZacb_3c2RhC22OA3vmOEgiYAJG3Dnpskm_XLxLr553btRPXJQih3cZoEwiTNW3twpOjc3Yyg5bw4lBH7P3h_m3ylE5fHp8nd9PUylz06VjJcqbqXCJiWddKN9hAUY4tApSgK5vbSs50AY2uoSyg1oWVOxiqsR5XVo3Y9X7vOvjPDVJvVo4sti106DdklOBlpZRUKqL5HrXBEwWcmXVwKwhbI7jZuTVLs3drdm4N1ya6jWNXhwubeoXN39CvzAjc7gGMf345DHGLw85i40KUaxrv_r_wA6yikCc</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>3106733233</pqid></control><display><type>article</type><title>Retinal electrophysiological alterations are associated with cognition in early course psychosis</title><source>MEDLINE</source><source>Elsevier ScienceDirect Journals Complete</source><creator>Molho, Willa ; Stiltner, Brendan ; Raymond, Nicolas ; Kiely, Chelsea ; Trotti, Rebekah ; Harris, Caroline ; Bannai, Deepthi ; Keshavan, Matcheri ; Silverstein, Steven ; Lizano, Paulo</creator><creatorcontrib>Molho, Willa ; Stiltner, Brendan ; Raymond, Nicolas ; Kiely, Chelsea ; Trotti, Rebekah ; Harris, Caroline ; Bannai, Deepthi ; Keshavan, Matcheri ; Silverstein, Steven ; Lizano, Paulo</creatorcontrib><description>Retinal electrophysiological alterations are implicated in psychosis, but their relationship with cognition in early course psychosis (ECP) is understudied. The Brief Assessment of Cognition (BAC) and flash electroretinography (fERG) were conducted in 24 controls (HC) and 27 ECP individuals. Partial Spearman correlations were performed between fERG and BAC. Lower Photopic-1b and Scotopic-3b amplitudes were identified in ECP vs. HCs. Correlations were significant (p<0.05) between BAC Composite score and a-wave S3a and S2a and b-wave S2b and S3b conditions. Thus, ECP was characterized by lower ERG responses, and lower rod/cone/bipolar cell responses were related to poorer cognition.</description><identifier>ISSN: 0920-9964</identifier><identifier>ISSN: 1573-2509</identifier><identifier>EISSN: 1573-2509</identifier><identifier>DOI: 10.1016/j.schres.2024.09.013</identifier><identifier>PMID: 39293251</identifier><language>eng</language><publisher>Netherlands: Elsevier B.V</publisher><subject>Adolescent ; Adult ; Cognition ; Cognitive Dysfunction - etiology ; Cognitive Dysfunction - physiopathology ; Early course psychosis ; Electroretinography ; Female ; Flash electroretinography ; Humans ; Male ; Psychosis ; Psychotic Disorders - physiopathology ; Retina - physiopathology ; Retinography ; Young Adult</subject><ispartof>Schizophrenia research, 2024-12, Vol.274, p.137-141</ispartof><rights>2024 Elsevier B.V.</rights><rights>Copyright © 2024 Elsevier B.V. All rights reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c241t-8326f3b42eee6bb39deda568ceaa6a97c4c72f95ad9ba65ab95c22eeea78987c3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.schres.2024.09.013$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,780,784,3550,27924,27925,45995</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/39293251$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Molho, Willa</creatorcontrib><creatorcontrib>Stiltner, Brendan</creatorcontrib><creatorcontrib>Raymond, Nicolas</creatorcontrib><creatorcontrib>Kiely, Chelsea</creatorcontrib><creatorcontrib>Trotti, Rebekah</creatorcontrib><creatorcontrib>Harris, Caroline</creatorcontrib><creatorcontrib>Bannai, Deepthi</creatorcontrib><creatorcontrib>Keshavan, Matcheri</creatorcontrib><creatorcontrib>Silverstein, Steven</creatorcontrib><creatorcontrib>Lizano, Paulo</creatorcontrib><title>Retinal electrophysiological alterations are associated with cognition in early course psychosis</title><title>Schizophrenia research</title><addtitle>Schizophr Res</addtitle><description>Retinal electrophysiological alterations are implicated in psychosis, but their relationship with cognition in early course psychosis (ECP) is understudied. The Brief Assessment of Cognition (BAC) and flash electroretinography (fERG) were conducted in 24 controls (HC) and 27 ECP individuals. Partial Spearman correlations were performed between fERG and BAC. Lower Photopic-1b and Scotopic-3b amplitudes were identified in ECP vs. HCs. Correlations were significant (p<0.05) between BAC Composite score and a-wave S3a and S2a and b-wave S2b and S3b conditions. Thus, ECP was characterized by lower ERG responses, and lower rod/cone/bipolar cell responses were related to poorer cognition.</description><subject>Adolescent</subject><subject>Adult</subject><subject>Cognition</subject><subject>Cognitive Dysfunction - etiology</subject><subject>Cognitive Dysfunction - physiopathology</subject><subject>Early course psychosis</subject><subject>Electroretinography</subject><subject>Female</subject><subject>Flash electroretinography</subject><subject>Humans</subject><subject>Male</subject><subject>Psychosis</subject><subject>Psychotic Disorders - physiopathology</subject><subject>Retina - physiopathology</subject><subject>Retinography</subject><subject>Young Adult</subject><issn>0920-9964</issn><issn>1573-2509</issn><issn>1573-2509</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2024</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kE1LAzEQhoMotlb_gcgeveyaj_1oLoIUv6AgiJ7jbHbapmw3NbNV-u9NafXoaeCdZ2aYh7FLwTPBRXmzzMguAlImucwzrjMu1BEbiqJSqSy4PmZDriVPtS7zATsjWnLORcGrUzZQWmolCzFkH6_Yuw7aBFu0ffDrxZacb_3c2RhC22OA3vmOEgiYAJG3Dnpskm_XLxLr553btRPXJQih3cZoEwiTNW3twpOjc3Yyg5bw4lBH7P3h_m3ylE5fHp8nd9PUylz06VjJcqbqXCJiWddKN9hAUY4tApSgK5vbSs50AY2uoSyg1oWVOxiqsR5XVo3Y9X7vOvjPDVJvVo4sti106DdklOBlpZRUKqL5HrXBEwWcmXVwKwhbI7jZuTVLs3drdm4N1ya6jWNXhwubeoXN39CvzAjc7gGMf345DHGLw85i40KUaxrv_r_wA6yikCc</recordid><startdate>202412</startdate><enddate>202412</enddate><creator>Molho, Willa</creator><creator>Stiltner, Brendan</creator><creator>Raymond, Nicolas</creator><creator>Kiely, Chelsea</creator><creator>Trotti, Rebekah</creator><creator>Harris, Caroline</creator><creator>Bannai, Deepthi</creator><creator>Keshavan, Matcheri</creator><creator>Silverstein, Steven</creator><creator>Lizano, Paulo</creator><general>Elsevier B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>202412</creationdate><title>Retinal electrophysiological alterations are associated with cognition in early course psychosis</title><author>Molho, Willa ; Stiltner, Brendan ; Raymond, Nicolas ; Kiely, Chelsea ; Trotti, Rebekah ; Harris, Caroline ; Bannai, Deepthi ; Keshavan, Matcheri ; Silverstein, Steven ; Lizano, Paulo</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c241t-8326f3b42eee6bb39deda568ceaa6a97c4c72f95ad9ba65ab95c22eeea78987c3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2024</creationdate><topic>Adolescent</topic><topic>Adult</topic><topic>Cognition</topic><topic>Cognitive Dysfunction - etiology</topic><topic>Cognitive Dysfunction - physiopathology</topic><topic>Early course psychosis</topic><topic>Electroretinography</topic><topic>Female</topic><topic>Flash electroretinography</topic><topic>Humans</topic><topic>Male</topic><topic>Psychosis</topic><topic>Psychotic Disorders - physiopathology</topic><topic>Retina - physiopathology</topic><topic>Retinography</topic><topic>Young Adult</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Molho, Willa</creatorcontrib><creatorcontrib>Stiltner, Brendan</creatorcontrib><creatorcontrib>Raymond, Nicolas</creatorcontrib><creatorcontrib>Kiely, Chelsea</creatorcontrib><creatorcontrib>Trotti, Rebekah</creatorcontrib><creatorcontrib>Harris, Caroline</creatorcontrib><creatorcontrib>Bannai, Deepthi</creatorcontrib><creatorcontrib>Keshavan, Matcheri</creatorcontrib><creatorcontrib>Silverstein, Steven</creatorcontrib><creatorcontrib>Lizano, Paulo</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Schizophrenia research</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Molho, Willa</au><au>Stiltner, Brendan</au><au>Raymond, Nicolas</au><au>Kiely, Chelsea</au><au>Trotti, Rebekah</au><au>Harris, Caroline</au><au>Bannai, Deepthi</au><au>Keshavan, Matcheri</au><au>Silverstein, Steven</au><au>Lizano, Paulo</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Retinal electrophysiological alterations are associated with cognition in early course psychosis</atitle><jtitle>Schizophrenia research</jtitle><addtitle>Schizophr Res</addtitle><date>2024-12</date><risdate>2024</risdate><volume>274</volume><spage>137</spage><epage>141</epage><pages>137-141</pages><issn>0920-9964</issn><issn>1573-2509</issn><eissn>1573-2509</eissn><abstract>Retinal electrophysiological alterations are implicated in psychosis, but their relationship with cognition in early course psychosis (ECP) is understudied. The Brief Assessment of Cognition (BAC) and flash electroretinography (fERG) were conducted in 24 controls (HC) and 27 ECP individuals. Partial Spearman correlations were performed between fERG and BAC. Lower Photopic-1b and Scotopic-3b amplitudes were identified in ECP vs. HCs. Correlations were significant (p<0.05) between BAC Composite score and a-wave S3a and S2a and b-wave S2b and S3b conditions. Thus, ECP was characterized by lower ERG responses, and lower rod/cone/bipolar cell responses were related to poorer cognition.</abstract><cop>Netherlands</cop><pub>Elsevier B.V</pub><pmid>39293251</pmid><doi>10.1016/j.schres.2024.09.013</doi><tpages>5</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0920-9964 |
| ispartof | Schizophrenia research, 2024-12, Vol.274, p.137-141 |
| issn | 0920-9964 1573-2509 1573-2509 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_3106733233 |
| source | MEDLINE; Elsevier ScienceDirect Journals Complete |
| subjects | Adolescent Adult Cognition Cognitive Dysfunction - etiology Cognitive Dysfunction - physiopathology Early course psychosis Electroretinography Female Flash electroretinography Humans Male Psychosis Psychotic Disorders - physiopathology Retina - physiopathology Retinography Young Adult |
| title | Retinal electrophysiological alterations are associated with cognition in early course psychosis |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2024-12-28T21%3A52%3A27IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Retinal%20electrophysiological%20alterations%20are%20associated%20with%20cognition%20in%20early%20course%20psychosis&rft.jtitle=Schizophrenia%20research&rft.au=Molho,%20Willa&rft.date=2024-12&rft.volume=274&rft.spage=137&rft.epage=141&rft.pages=137-141&rft.issn=0920-9964&rft.eissn=1573-2509&rft_id=info:doi/10.1016/j.schres.2024.09.013&rft_dat=%3Cproquest_cross%3E3106733233%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=3106733233&rft_id=info:pmid/39293251&rft_els_id=S0920996424004195&rfr_iscdi=true |