Intact HIV reservoir in monocytes is associated with cognitive function in virally suppressed women with HIV

Intact HIV reservoir in monocytes is associated with cognitive function in virally suppressed women with HIV

Monocytes are susceptible to HIV infection, form HIV reservoirs, and contribute to central nervous system complications (e.g., cognitive impairment) in virally suppressed women with HIV(vsWWH). However, it remains unknown if the quality and/or quantity of the monocyte reservoir contributes to cognit...

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Veröffentlicht in:The Journal of infectious diseases 2024-09
Hauptverfasser: Rubin, Leah H, Shirk, Erin N, Pohlenz, Lily, Romero, Hayley, Roti, Elizabeth, Dastgheyb, Raha M, Santiuste, Isabel, Coughlin, Jennifer M, Brown, Todd T, Clements, Janice E, Veenhuis, Rebecca T
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Sprache:eng
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Zusammenfassung:Monocytes are susceptible to HIV infection, form HIV reservoirs, and contribute to central nervous system complications (e.g., cognitive impairment) in virally suppressed women with HIV(vsWWH). However, it remains unknown if the quality and/or quantity of the monocyte reservoir contributes to cognition in vsWWH. 62 vsWWH(mean age=56.1, SD=7.1; 93% Black, non-Hispanic; all HIV RNA
ISSN:0022-1899
1537-6613
1537-6613
DOI:10.1093/infdis/jiae460