Protein Intake and High Uric Acid Stone Risk
We evaluated the metabolic differences between pure and impure uric acid stone formers in this retrospective study of uric acid kidney stone formers diagnosed between 1996 and 2021. Demographics and medical history were compared by χ2 tests. Twenty-four-hour urine chemistries were compared using log...
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| Veröffentlicht in: | Kidney medicine 2024-09, Vol.6 (9), p.100878, Article 100878 |
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| creator | Montgomery, Tinika A. Nair, Hari R. Phadke, Manali Morhardt, Erin Ludvigson, Adam Motamedinia, Piruz Singh, Dinesh Dahl, Neera K. |
| description | We evaluated the metabolic differences between pure and impure uric acid stone formers in this retrospective study of uric acid kidney stone formers diagnosed between 1996 and 2021.
Demographics and medical history were compared by χ2 tests. Twenty-four-hour urine chemistries were compared using logistic regressions while controlling for demographics and comorbid conditions.
Patients from Yale Urology and Nephrology Clinics with a documented kidney stone analysis containing uric acid were included. In total, 4,294 kidney stone formers had a stone analysis, and 722 (16.8%) contained uric acid. Patients with all stone analyses≥ 50% uric acid were allocated to the pure group, while patients with≥1 stone analysis |
| doi_str_mv | 10.1016/j.xkme.2024.100878 |
| format | Article |
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Demographics and medical history were compared by χ2 tests. Twenty-four-hour urine chemistries were compared using logistic regressions while controlling for demographics and comorbid conditions.
Patients from Yale Urology and Nephrology Clinics with a documented kidney stone analysis containing uric acid were included. In total, 4,294 kidney stone formers had a stone analysis, and 722 (16.8%) contained uric acid. Patients with all stone analyses≥ 50% uric acid were allocated to the pure group, while patients with≥1 stone analysis<50% uric acid were allocated to the impure group.
Among kidney stone formers, the prevalence of uric acid nephrolithiasis was 16.8%. Pure uric acid stone formers were more likely to be older, heavier, and were 1.5 times more likely to have chronic kidney disease. When controlling for age, sex, race, ethnicity, and body mass index, pure uric acid stone formers had lower urinary pH and lower urine citrate normalized for creatinine. Additionally, they had a higher protein catabolic rate, urine urea nitrogen, and urine sulfur normalized for creatinine, all markers of dietary protein intake. These findings persisted after controlling for chronic kidney disease.
This is a retrospective study from a single center.
Pure uric acid stone formation is more common with diminished kidney function; however, after controlling for kidney function, pure uric acid stone formation is associated with protein intake, suggesting that modifying protein intake may reduce risk.</description><identifier>ISSN: 2590-0595</identifier><identifier>EISSN: 2590-0595</identifier><identifier>DOI: 10.1016/j.xkme.2024.100878</identifier><identifier>PMID: 39279882</identifier><language>eng</language><publisher>United States: Elsevier Inc</publisher><subject>Chronic kidney disease ; protein intake ; uric acid stones</subject><ispartof>Kidney medicine, 2024-09, Vol.6 (9), p.100878, Article 100878</ispartof><rights>2024 The Authors</rights><rights>2024 The Authors.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c281t-1daf721a3e177ce9872381abe7c1eff358a47c3810d8a5fe14eb1c37bb8225f73</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,860,27901,27902</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/39279882$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Montgomery, Tinika A.</creatorcontrib><creatorcontrib>Nair, Hari R.</creatorcontrib><creatorcontrib>Phadke, Manali</creatorcontrib><creatorcontrib>Morhardt, Erin</creatorcontrib><creatorcontrib>Ludvigson, Adam</creatorcontrib><creatorcontrib>Motamedinia, Piruz</creatorcontrib><creatorcontrib>Singh, Dinesh</creatorcontrib><creatorcontrib>Dahl, Neera K.</creatorcontrib><title>Protein Intake and High Uric Acid Stone Risk</title><title>Kidney medicine</title><addtitle>Kidney Med</addtitle><description>We evaluated the metabolic differences between pure and impure uric acid stone formers in this retrospective study of uric acid kidney stone formers diagnosed between 1996 and 2021.
Demographics and medical history were compared by χ2 tests. Twenty-four-hour urine chemistries were compared using logistic regressions while controlling for demographics and comorbid conditions.
Patients from Yale Urology and Nephrology Clinics with a documented kidney stone analysis containing uric acid were included. In total, 4,294 kidney stone formers had a stone analysis, and 722 (16.8%) contained uric acid. Patients with all stone analyses≥ 50% uric acid were allocated to the pure group, while patients with≥1 stone analysis<50% uric acid were allocated to the impure group.
Among kidney stone formers, the prevalence of uric acid nephrolithiasis was 16.8%. Pure uric acid stone formers were more likely to be older, heavier, and were 1.5 times more likely to have chronic kidney disease. When controlling for age, sex, race, ethnicity, and body mass index, pure uric acid stone formers had lower urinary pH and lower urine citrate normalized for creatinine. Additionally, they had a higher protein catabolic rate, urine urea nitrogen, and urine sulfur normalized for creatinine, all markers of dietary protein intake. These findings persisted after controlling for chronic kidney disease.
This is a retrospective study from a single center.
Pure uric acid stone formation is more common with diminished kidney function; however, after controlling for kidney function, pure uric acid stone formation is associated with protein intake, suggesting that modifying protein intake may reduce risk.</description><subject>Chronic kidney disease</subject><subject>protein intake</subject><subject>uric acid stones</subject><issn>2590-0595</issn><issn>2590-0595</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2024</creationdate><recordtype>article</recordtype><recordid>eNp9kE1Lw0AQhhdRbKn9Ax4kRw-m7md3A15KUVsoKGrPy2Yzq9s2Sd1NRf-9KaniydMMw_O-MA9C5wSPCCbj69Xoc13CiGLK2wNWUh2hPhUZTrHIxPGfvYeGMa4wxpTy8ZjwU9RjGZWZUrSPrh5D3YCvknnVmDUkpiqSmX99S5bB22RifZE8N3UFyZOP6zN04swmwvAwB2h5d_synaWLh_v5dLJILVWkSUlhnKTEMCBSWsiUpEwRk4O0BJxjQhkubXvChTLCAeGQE8tknitKhZNsgC673m2o33cQG136aGGzMRXUu6gZwYJnjGPcorRDbahjDOD0NvjShC9NsN6L0iu9F6X3onQnqg1dHPp3eQnFb-RHSwvcdAC0X354CDpaD5WFwgewjS5q_1__N6bUdv0</recordid><startdate>202409</startdate><enddate>202409</enddate><creator>Montgomery, Tinika A.</creator><creator>Nair, Hari R.</creator><creator>Phadke, Manali</creator><creator>Morhardt, Erin</creator><creator>Ludvigson, Adam</creator><creator>Motamedinia, Piruz</creator><creator>Singh, Dinesh</creator><creator>Dahl, Neera K.</creator><general>Elsevier Inc</general><scope>6I.</scope><scope>AAFTH</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>202409</creationdate><title>Protein Intake and High Uric Acid Stone Risk</title><author>Montgomery, Tinika A. ; Nair, Hari R. ; Phadke, Manali ; Morhardt, Erin ; Ludvigson, Adam ; Motamedinia, Piruz ; Singh, Dinesh ; Dahl, Neera K.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c281t-1daf721a3e177ce9872381abe7c1eff358a47c3810d8a5fe14eb1c37bb8225f73</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2024</creationdate><topic>Chronic kidney disease</topic><topic>protein intake</topic><topic>uric acid stones</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Montgomery, Tinika A.</creatorcontrib><creatorcontrib>Nair, Hari R.</creatorcontrib><creatorcontrib>Phadke, Manali</creatorcontrib><creatorcontrib>Morhardt, Erin</creatorcontrib><creatorcontrib>Ludvigson, Adam</creatorcontrib><creatorcontrib>Motamedinia, Piruz</creatorcontrib><creatorcontrib>Singh, Dinesh</creatorcontrib><creatorcontrib>Dahl, Neera K.</creatorcontrib><collection>ScienceDirect Open Access Titles</collection><collection>Elsevier:ScienceDirect:Open Access</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Kidney medicine</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Montgomery, Tinika A.</au><au>Nair, Hari R.</au><au>Phadke, Manali</au><au>Morhardt, Erin</au><au>Ludvigson, Adam</au><au>Motamedinia, Piruz</au><au>Singh, Dinesh</au><au>Dahl, Neera K.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Protein Intake and High Uric Acid Stone Risk</atitle><jtitle>Kidney medicine</jtitle><addtitle>Kidney Med</addtitle><date>2024-09</date><risdate>2024</risdate><volume>6</volume><issue>9</issue><spage>100878</spage><pages>100878-</pages><artnum>100878</artnum><issn>2590-0595</issn><eissn>2590-0595</eissn><abstract>We evaluated the metabolic differences between pure and impure uric acid stone formers in this retrospective study of uric acid kidney stone formers diagnosed between 1996 and 2021.
Demographics and medical history were compared by χ2 tests. Twenty-four-hour urine chemistries were compared using logistic regressions while controlling for demographics and comorbid conditions.
Patients from Yale Urology and Nephrology Clinics with a documented kidney stone analysis containing uric acid were included. In total, 4,294 kidney stone formers had a stone analysis, and 722 (16.8%) contained uric acid. Patients with all stone analyses≥ 50% uric acid were allocated to the pure group, while patients with≥1 stone analysis<50% uric acid were allocated to the impure group.
Among kidney stone formers, the prevalence of uric acid nephrolithiasis was 16.8%. Pure uric acid stone formers were more likely to be older, heavier, and were 1.5 times more likely to have chronic kidney disease. When controlling for age, sex, race, ethnicity, and body mass index, pure uric acid stone formers had lower urinary pH and lower urine citrate normalized for creatinine. Additionally, they had a higher protein catabolic rate, urine urea nitrogen, and urine sulfur normalized for creatinine, all markers of dietary protein intake. These findings persisted after controlling for chronic kidney disease.
This is a retrospective study from a single center.
Pure uric acid stone formation is more common with diminished kidney function; however, after controlling for kidney function, pure uric acid stone formation is associated with protein intake, suggesting that modifying protein intake may reduce risk.</abstract><cop>United States</cop><pub>Elsevier Inc</pub><pmid>39279882</pmid><doi>10.1016/j.xkme.2024.100878</doi><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
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| ispartof | Kidney medicine, 2024-09, Vol.6 (9), p.100878, Article 100878 |
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| source | DOAJ Directory of Open Access Journals; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; PubMed Central; Alma/SFX Local Collection |
| subjects | Chronic kidney disease protein intake uric acid stones |
| title | Protein Intake and High Uric Acid Stone Risk |
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