Improved Composite Hydrogel for Bioengineered Tracheal Graft Demonstrates Effective Early Angiogenesis

Improved Composite Hydrogel for Bioengineered Tracheal Graft Demonstrates Effective Early Angiogenesis

: Collagen-agarose hydrogel blends currently used in tracheal graft bioengineering contain relatively high concentrations of collagen to withstand mechanical stresses associated with native trachea function (e.g., breathing). Unfortunately, the high collagen content restricts effective cell infiltra...

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Veröffentlicht in:Journal of clinical medicine 2024-08, Vol.13 (17), p.5148
Hauptverfasser: Martins, Russell Seth, Weber, Joanna, Drake, Lauren, Latif, M Jawad, Poulikidis, Kostantinos, Razi, Syed Shahzad, Luo, Jeffrey, Bhora, Faiz Y
Format: Artikel
Sprache:eng
Schlagworte:
Angiogenesis
Bioengineering
Cells
Collagen
Fibroblasts
Hydrogels
Hypoxia
Morphology
Nitric oxide
Tissue engineering
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Zusammenfassung:: Collagen-agarose hydrogel blends currently used in tracheal graft bioengineering contain relatively high concentrations of collagen to withstand mechanical stresses associated with native trachea function (e.g., breathing). Unfortunately, the high collagen content restricts effective cell infiltration into the hydrogel. In this study, we created an improved hydrogel blend with lower concentrations of collagen (
ISSN:2077-0383
2077-0383
DOI:10.3390/jcm13175148