Monovalent rotavirus vaccine effectiveness and long-term impact among children <5 years old in Antananarivo, Madagascar, 2010–2022

Monovalent rotavirus vaccine substantially reduced rotavirus disease burden after introduction (May 2014) in Madagascar. We examined the effectiveness and long-term impact on acute watery diarrhea and rotavirus-related hospitalizations among children 50 % of the genotypes detected post-introduction....

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Veröffentlicht in:	Vaccine 2024-12, Vol.42 (26), p.126321, Article 126321
Hauptverfasser:	Raboba, Julia Liliane, Rahajamanana, Vonintsoa Lalaina, Rakotojoelimaria, Haganiaina Elsa, Masembe, Yolande Vuo, Martin, Patricia Rasoamihanta, Weldegebriel, Goitom G., Diallo, Alpha Oumar, Burnett, Eleanor, Tate, Jaqueline E., Parashar, Umesh D., Mwenda, Jason M., Seheri, Mapaseka, Magagula, Nonkululeko, Mphahlele, Jeffrey, Robinson, Annick Lalaina
Format:	Artikel
Sprache:	eng
Schlagworte:	Age Age groups Case-Control Studies Child, Preschool Children Diarrhea Diarrhea - epidemiology Diarrhea - prevention & control Diarrhea - virology Disease Effectiveness Female Genotype Genotypes Hospitalization Hospitalization - statistics & numerical data Hospitals Humans Immunization Immunization Programs Infant Infant, Newborn Low income groups Madagascar Madagascar - epidemiology Male Malnutrition Nutritional status Pediatrics Rotavirus Rotavirus - genetics Rotavirus - immunology Rotavirus Infections - epidemiology Rotavirus Infections - prevention & control Rotavirus surveillance Rotavirus vaccine effectiveness Rotavirus vaccine impact Rotavirus Vaccines - administration & dosage Rotavirus Vaccines - immunology Rotavirus Vaccines - therapeutic use Seasons Software Surveillance Vaccination - statistics & numerical data Vaccine efficacy Vaccine Efficacy - statistics & numerical data Vaccines Vaccines, Attenuated - administration & dosage Vaccines, Attenuated - immunology Viruses
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Zusammenfassung:	Monovalent rotavirus vaccine substantially reduced rotavirus disease burden after introduction (May 2014) in Madagascar. We examined the effectiveness and long-term impact on acute watery diarrhea and rotavirus-related hospitalizations among children 50 % of the genotypes detected post-introduction. Rotavirus vaccine has been successfully implemented in Madagascar's routine childhood immunization program and had a large impact on rotavirus disease burden, supporting continued use of rotavirus vaccines in Madagascar.
ISSN:	0264-410X 1873-2518 1873-2518
DOI:	10.1016/j.vaccine.2024.126321