Comparing the different phenotypes of diabetes in pregnancy: Are outcomes worse for women with young-onset type 2 diabetes compared to type 1 diabetes?

Pregnancies are increasingly affected by young-onset type 2 diabetes mellitus (YT2DM), an aggressive phenotype associated with a higher vascular risk profile compared to type 1 diabetes mellitus (T1DM). We compared pregnancy outcomes to illuminate areas where differing management guidance might be n...

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Veröffentlicht in:	Diabetes research and clinical practice 2024-11, Vol.217, p.111848, Article 111848
Hauptverfasser:	Zhen, Xi May, Ross, Glynis, Gauld, Amanda, Nettel-Aguirre, Alberto, Noonan, Stephanie, Constantino, Maria, Sweeting, Arianne, Harding, Anna-Jane, Mackie, Adam, Chatila, Hend, McGill, Margaret, Middleton, Timothy, Wu, Ted, Twigg, Stephen, Wong, Jencia
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Age of Onset Diabetes Mellitus, Type 1 - complications Diabetes Mellitus, Type 1 - epidemiology Diabetes Mellitus, Type 2 - epidemiology Female Humans Infant, Newborn Phenotype Pre-Eclampsia - epidemiology Pregnancy Pregnancy in Diabetics - epidemiology Pregnancy Outcome - epidemiology Premature Birth - epidemiology Retrospective Studies Type 1 diabetes Type 2 diabetes Young Adult Young-onset
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Zusammenfassung:	Pregnancies are increasingly affected by young-onset type 2 diabetes mellitus (YT2DM), an aggressive phenotype associated with a higher vascular risk profile compared to type 1 diabetes mellitus (T1DM). We compared pregnancy outcomes to illuminate areas where differing management guidance might be needed. This retrospective single-centre study (2010 2019) included 259 singleton pregnancies affected by pregestational T1DM (N = 124) or YT2DM (N = 135) diagnosed at
ISSN:	0168-8227 1872-8227 1872-8227
DOI:	10.1016/j.diabres.2024.111848