Au(III)/TPPMS-catalyzed Friedel-Crafts benzylation of deactivated N -alkylanilines in water
The Friedel-Crafts reaction of electronically deactivated anilines including those with strong electron-withdrawing NO , CN or CO H groups is challenging due to the reduced electron density of the aromatic ring. Here, we demonstrate the Au(III)/TPPMS-catalyzed Friedel-Crafts benzylation of deactivat...
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Veröffentlicht in: | Organic & biomolecular chemistry 2024-10, Vol.22 (38), p.7874-7879 |
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Hauptverfasser: | , , , , , , |
Format: | Artikel |
Sprache: | eng |
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Zusammenfassung: | The Friedel-Crafts reaction of electronically deactivated anilines including those with strong electron-withdrawing NO
, CN or CO
H groups is challenging due to the reduced electron density of the aromatic ring. Here, we demonstrate the Au(III)/TPPMS-catalyzed Friedel-Crafts benzylation of deactivated anilines in water. This reaction exhibits operational simplicity and a broad substrate scope with high regioselectivity, enabling rapid access to 2-benzylanilines. |
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ISSN: | 1477-0520 1477-0539 1477-0539 |
DOI: | 10.1039/d4ob01234h |