BCMA-Targeted T-Cell–Engager Therapy for Autoimmune Disease

In four patients with severe autoimmune disease, teclistimab, a bispecific antibody to B-cell maturation antigen and CD3, resulted in autoantibody reduction and clinical response after short-term follow-up.

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Bibliographische Detailangaben
Veröffentlicht in:	The New England journal of medicine 2024-09, Vol.391 (9), p.867-869
Hauptverfasser:	Hagen, Melanie, Bucci, Laura, Böltz, Sebastian, Nöthling, Danae-Mona, Rothe, Tobias, Anoshkin, Kirill, Raimondo, Maria G., Tur, Carlo, Wirsching, Andreas, Wacker, Jochen, Düsing, Christina, Distler, Jörg H.W., Kuwert, Torsten, Bozec, Aline, Ramming, Andreas, Schett, Georg, Grieshaber-Bouyer, Ricardo
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Allergy Antibodies, Bispecific - administration & dosage Antigens Autoantibodies Autoimmune Disease Autoimmune diseases Autoimmune Diseases - drug therapy Autoimmune Diseases - immunology B-Cell Maturation Antigen - antagonists & inhibitors B-Cell Maturation Antigen - immunology Bispecific antibodies CD3 antigen Clinical Medicine Clinical Medicine General Critical Care Critical Care General Cytokine storm Dermatology Dermatology General Female Grants Hematology Humans Immunology Immunology General Immunosuppressive agents Immunosuppressive Agents - administration & dosage Immunosuppressive Agents - adverse effects Infections Inflammatory Disease Lung diseases Lymphocytes Lymphocytes B Lymphocytes T Middle Aged Nephrology Nephrology General Neurotoxicity Oncology Oncology General Patients Plasma Psoriasis Pulmonary Rheumatoid Arthritis Rheumatology Rheumatology General Scleroderma T-Cells T-Lymphocytes - drug effects T-Lymphocytes - immunology Tomography Treatment Outcome Vasculitis
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Beschreibung
Zusammenfassung:	In four patients with severe autoimmune disease, teclistimab, a bispecific antibody to B-cell maturation antigen and CD3, resulted in autoantibody reduction and clinical response after short-term follow-up.
ISSN:	0028-4793 1533-4406 1533-4406
DOI:	10.1056/NEJMc2408786