Effects of disease-modifying therapies on remyelination in multiple sclerosis; evaluation via visual evoked potential test

•VEP is one of the most sensitive methods to demonstrate myelin integrity, remyelination capacity and axonal dysfunction.•Deterioration in VEP is associated with disease duration or higher EDSS. This may be an indirect consequence of axonal degeneration dominating remyelination by process.DMTs do no...

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Veröffentlicht in:Multiple sclerosis and related disorders 2024-11, Vol.91, p.105850, Article 105850
Hauptverfasser: Saridas, Furkan, Hojjati, Farid, Alizada, Shanay, Lazrak, Sarra, Koc, Emine Rabia, Turan, Omer Faruk
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Sprache:eng
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Zusammenfassung:•VEP is one of the most sensitive methods to demonstrate myelin integrity, remyelination capacity and axonal dysfunction.•Deterioration in VEP is associated with disease duration or higher EDSS. This may be an indirect consequence of axonal degeneration dominating remyelination by process.DMTs do not ameliorate impaired remyelination and neurodegeneration, but appear to be sufficient for short-term maintenance of the current state.•Further studies with larger numbers of patients and longer follow-up periods are needed among homogeneous patient groups for DMTs. Assessment of the visual pathway, which is frequently affected by MS, provides the opportunity to measure the remyelination of acute and chronic MS lesions in vivo and non-invasively. VEP can be used in this context. Amplitude is a parameter of axonal loss, whereas latency is an in vivo biomarker of myelin repair. This study aimed to evaluate DMT's neuroprotective and pro-remyelinating potential by evaluating VEP latency and amplitude in MS patients. A total of 74 patients with relapsing MS who had no evidence of optic neuritis were included in the study. Patient data were retrospectively analyzed and recorded. In the VEP test, latency above 118 ms and amplitude below 5.0 μV were considered abnormal. Classified according to DMTs (injectables, teriflunomide, dimethyl fumarate, fingolimod, cladribine, and alemtuzumab). Visual evoked potential tests, clinical features, and cerebrospinal fluid examinations were evaluated by three independent neurologists (one of whom was also a clinical neurophysiologist). The mean age at diagnosis was 29.2 ± 9.01, and the mean age at first VEP was 34.97 ± 10.64. In women, latency was lower, and amplitude was higher. The mean differences in latency and amplitude were, respectively, latency prolonged by 0.7 ms on the right and 0.5 ms on the left, and amplitude increased by 0.6 μV on the right and 0.37 μV on the left. However, these changes were not statistically significant. Latency worsening was more prominent in those with longer disease duration (p = 0.011). Those with amplitude or latency worsening had higher EDSS (p = 0.016 and 0.013, respectively). DMTs did not affect these changes. Prolonged latency is associated with a long disease duration. Deterioration in both amplitude and latency is evident in high EDSS. These results may be an indirect consequence of axonal degeneration dominating remyelination. DMTs do not ameliorate impaired remyelination and neurodegenera
ISSN:2211-0348
2211-0356
2211-0356
DOI:10.1016/j.msard.2024.105850