Adjunctive Intravenous Argatroban or Eptifibatide for Ischemic Stroke

In this trial involving patients with acute ischemic stroke treated with thrombolysis within 3 hours after symptom onset, the use of adjunctive intravenous argatroban or eptifibatide did not improve 90-day poststroke outcomes.

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Bibliographische Detailangaben
Veröffentlicht in:	The New England journal of medicine 2024-09, Vol.391 (9), p.810-820
Hauptverfasser:	Adeoye, Opeolu, Broderick, Joseph, Derdeyn, Colin P., Grotta, James C., Barsan, William, Bentho, Oladi, Berry, Scott, Concha, Mauricio, Davis, Iris, Demel, Stacie, Elm, Jordan, Gentile, Nina, Graves, Todd, Hoffman, Melissa, Huang, Josephine, Ingles, James, Janis, Scott, Jasne, Adam S., Khatri, Pooja, Levine, Steven R., Majjhoo, Aniel, Panagos, Peter, Pancioli, Arthur, Pizzella, Stephanie, Ranasinghe, Tamra, Sabagha, Noor, Sivakumar, Sanjeev, Streib, Christopher, Vagal, Achala, Wilson, Alastair, Wintermark, Max, Yoo, Albert J., Barreto, Andrew D.
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Aged Aging Aging General Anticoagulants - administration & dosage Anticoagulants - adverse effects Anticoagulation Arginine - administration & dosage Arginine - adverse effects Arginine - analogs & derivatives Cardiology Cardiology General Cardiovascular system Clinical Medicine Clinical Medicine General Clinical trials Coagulation Combined Modality Therapy - adverse effects Combined Modality Therapy - methods Critical Care Critical Care General Drug Therapy, Combination - adverse effects Drug Therapy, Combination - methods Emergency Medicine Emergency Medicine General Enrollments Eptifibatide - administration & dosage Eptifibatide - adverse effects Expected utility Female Fibrinolytic Agents - administration & dosage Fibrinolytic Agents - adverse effects Geriatrics Glycoproteins Hematology Hemorrhage Hospital-Based Clinical Medicine Humans Incidence Infusions, Intravenous Intracranial Hemorrhages - chemically induced Intracranial Hemorrhages - epidemiology Intravenous administration Ischemia Ischemic Stroke - mortality Ischemic Stroke - therapy Male Middle Aged Missing data Mortality Neurological diseases Neurology Neurosurgery Neurosurgery General Oncology Patients Peptides - administration & dosage Peptides - adverse effects Peptides - therapeutic use Peripheral Arterial and Aortic Disease Pipecolic Acids - administration & dosage Pipecolic Acids - adverse effects Placebos Platelet Aggregation Inhibitors - administration & dosage Platelet Aggregation Inhibitors - adverse effects Pulmonary Rehabilitation Single-Blind Method Statistical analysis Stroke Sulfonamides - administration & dosage Sulfonamides - adverse effects Thrombectomy - adverse effects Thrombectomy - methods Thromboembolism Thrombolysis Thrombolytic Therapy - adverse effects Treatment Outcome
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Beschreibung
Zusammenfassung:	In this trial involving patients with acute ischemic stroke treated with thrombolysis within 3 hours after symptom onset, the use of adjunctive intravenous argatroban or eptifibatide did not improve 90-day poststroke outcomes.
ISSN:	0028-4793 1533-4406 1533-4406
DOI:	10.1056/NEJMoa2314779