Gut microbiota derived short‐chain fatty acids in physiology and pathology: An update

Short‐chain fatty acids (SCFAs) are essential molecules produced by gut bacteria that fuel intestinal cells and may also influence overall health. An imbalance of SCFAs can result in various acute and chronic diseases, including diabetes, obesity and colorectal cancer (CRC). This review delves into the multifaceted roles of SCFAs, including a brief discussion on their source and various gut‐residing bacteria. Primary techniques used for detection of SCFAs, including gas chromatography, high‐performance gas chromatography, nuclear magnetic resonance and capillary electrophoresis are also discussed through this article. This review study also compiles various synthesis pathways of SCFAs from diverse substrates such as sugar, acetone, ethanol and amino acids. The different pathways through which SCFAs enter cells for immune response regulation are also highlighted. A major emphasis is the discussion on diseases associated with SCFA dysregulation, such as anaemia, brain development, CRC, depression, obesity and diabetes. This includes exploring the relationship between SCFA levels across ethnicities and their connection with blood pressure and CRC. In conclusion, this review highlights the critical role of SCFAs in maintaining gut health and their implications in various diseases, emphasizing the need for further research on SCFA detection, synthesis and their potential as diagnostic biomarkers. Future studies of SCFAs will pave the way for the development of novel diagnostic tools and therapeutic strategies for optimizing gut health and preventing diseases associated with SCFA dysregulation. Significance Statement Understanding the role of short‐chain fatty acids (SCFAs) is crucial because they are fundamental to maintaining colonic health and overall bodily function. Imbalances in SCFAs are linked to serious conditions like diabetes, obesity and colorectal cancer, making it essential to explore their regulation and impact. Additionally, studying the variations in SCFA levels across different ethnicities can provide insights into disease susceptibility and health disparities. Furthermore, advancing detection methods and developing sensors for SCFAs could revolutionize diagnostics, allowing for earlier and more precise intervention in metabolic and gut‐related diseases. Thus, this review addresses significant gaps in knowledge and technology that could lead to better health outcomes.