Genesis of ischemic ST segment changes: A study using precordial bipolar leads and regional vectorcardiograms

Precordial Bipolar Leads (PBLs), Weighted Unipolar Leads (WUL), and Regional Vectorcardiograms (RVCGs) are constructed using the same data recorded by a standard 12‑lead ECG, but they provide additional information not visible in the standard 12‑lead ECG (ECG) tracings. In previous studies during balloon occlusion of the LAD and RCA, we observed a complete ischemic inversion of the QRS waves, with folding of the loop and ST segment shift. In the present study, we aim to investigate this abnormality using new ECG methods. We hypothesize that utilizing PBL, WUL, and RVCG in patients with ischemia caused by total acute coronary artery occlusion enables the detection of specific abnormalities—such as changes in waveform time/amplitude, the presence of the omega sign, distortion and folding of RVCG loops, and alterations in loop direction in both the transverse and frontal planes—that are not easily discernible with a standard 12‑lead ECG. This enhanced detection aids in understanding the mechanisms underlying electrocardiographic changes and may assist in managing patients when diagnostic uncertainties arise. Thirty-three patients undergoing elective PTCA were studied before and after acute LAD (16 patients) or RCA (17 patients) occlusion, and their data were processed with new methods based on PBLs, WULs, and RVCGs. 1. In acute ischemia due to occlusion of the LAD and RCA, the most important current of injury occurs in the right to left axis. This axis is underestimated by the standard 12‑lead ECG and only partially complemented by leads V3R and V4R. 2. The two-dimensional presentation detects a new sign (the omega sign), not detectable in the classic ECG, but almost always present in ischemia. It also allows for an accurate identification of the J point. 3. Ischemic R wave peak delay results in distortion and folding of the RVCG loop and causes displacement of the J point and the ST segment. 4. Wave inversion changes the loop direction in the transverse and frontal plane. Precordial bipolar leads, weighted unipolar leads, and regional vectorcardiograms provide essential information omitted by the standard 12‑lead ECG.