Polymorph formation from solvate desolvation

Polymorph formation from solvate desolvation

Spironolactone (C24H32O4S) usually crystallizes into an orthorhombic phase, named Form II. Another orthorhombic phase, named Form I, is also known but seems difficult to obtain. Studies of the kinetics of desolvation of the ethanol solvate at room temperature showed that these two forms can be obtai...

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Veröffentlicht in:Journal of thermal analysis and calorimetry 2007-11, Vol.90 (2), p.337-339
Hauptverfasser: Nicolai, Beatrice, Espeau, P, Ceolin, R, Perrin, M-A, Zaske, L, Giovannini, J, Leveiller, F
Format: Artikel
Sprache:eng
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Zusammenfassung:Spironolactone (C24H32O4S) usually crystallizes into an orthorhombic phase, named Form II. Another orthorhombic phase, named Form I, is also known but seems difficult to obtain. Studies of the kinetics of desolvation of the ethanol solvate at room temperature showed that these two forms can be obtained through different mechanisms of desolvation.
ISSN:1388-6150
DOI:10.1007/s10973-007-8389-9