Is X chromosome inactivation a cause or effect of SLE?

Autoimmune diseases such as systemic lupus erythematosus preferentially affect women, and multiple hypotheses are under investigation to elucidate this phenomenon. Emerging research suggests that multiple pathophysiological mechanisms and pathways are likely involved, including several that involve...

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Veröffentlicht in:	Nature reviews. Rheumatology 2024-10, Vol.20 (10), p.599-600
Hauptverfasser:	Scofield, R. Hal, Lewis, Valerie M.
Format:	Artikel
Sprache:	eng
Schlagworte:	631/208 692/4023/1670/1613 Age Arthritis Autoimmune diseases Bias Disease Females Hypotheses Interferon Lupus Medicine Medicine & Public Health News & Views news-and-views Rheumatology Scleroderma Stem cells Systemic lupus erythematosus Veterans Womens health X chromosomes X-chromosome inactivation
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Beschreibung
Zusammenfassung:	Autoimmune diseases such as systemic lupus erythematosus preferentially affect women, and multiple hypotheses are under investigation to elucidate this phenomenon. Emerging research suggests that multiple pathophysiological mechanisms and pathways are likely involved, including several that involve the X chromosome, but is skewing of X chromosome inactivation one of them?
ISSN:	1759-4790 1759-4804 1759-4804
DOI:	10.1038/s41584-024-01159-9