Effect of maternal prebiotic supplementation on human milk immunological composition: Insights from the SYMBA study

Effect of maternal prebiotic supplementation on human milk immunological composition: Insights from the SYMBA study

Immunomodulatory proteins in human milk (HM) can shape infant immune development. However, strategies to modulate their levels are currently unknown. This study investigated whether maternal prebiotic supplementation alters the levels of immunomodulatory proteins in HM. The study was nested within t...

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Veröffentlicht in:Pediatric allergy and immunology 2024-09, Vol.35 (9), p.e14226
Hauptverfasser: Divakara, Nivedithaa, Dempsey, Zac, Saraswati, Chitra, Garssen, Johan, Silva, Desiree, Keelan, Jeffrey A, Christophersen, Claus T, Cooper, Matthew N, Prescott, Susan L, Palmer, Debra J, Verhasselt, Valerie, Macchiaverni, Patricia
Format: Artikel
Sprache:eng
Schlagworte:
Adult
Babies
Breast Feeding
Breast milk
Breastfeeding & lactation
Cytokines - metabolism
Dietary Supplements
Double-Blind Method
Female
Humans
Immunoglobulin G
Immunomodulation
Infant
Infant, Newborn
Infants
Lactation
Lactation - immunology
Male
Milk
Milk, Human - chemistry
Milk, Human - immunology
Oligosaccharides
Oligosaccharides - administration & dosage
Placebos
Prebiotics
Prebiotics - administration & dosage
Pregnancy
Protein composition
Proteins
Supplements
Thymic stromal lymphopoietin
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Zusammenfassung:Immunomodulatory proteins in human milk (HM) can shape infant immune development. However, strategies to modulate their levels are currently unknown. This study investigated whether maternal prebiotic supplementation alters the levels of immunomodulatory proteins in HM. The study was nested within the SYMBA double-blind randomized controlled trial (ACTRN12615001075572), which investigated the effects of maternal prebiotic (short-chain galacto-oligosaccharides/long-chain fructo-oligosaccharides) supplementation from
ISSN:0905-6157
1399-3038
1399-3038
DOI:10.1111/pai.14226