Preparation of ceftiofur-encapsulated hen-egg low-density lipoproteins and their antibacterial effects on intracellular Staphylococcus aureus

Hen egg low-density lipoprotein (heLDL), as alternative of serum-derived LDL, was used as drug delivery system of ceftiofur (CEF). The CEF-loaded hen egg low-density lipoprotein (CEF-heLDL) with complete apolipoprotein structure and high drug loading rate was synthesized, possesses suitable particle...

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Veröffentlicht in:International journal of biological macromolecules 2024-10, Vol.278 (Pt 4), p.134840, Article 134840
Hauptverfasser: Zhao, Yi, Mao, Wei, Liu, Bo, Wang, Yong-fei, Zhang, Shuang-yi, Guo, Li-li, Qian, Ying-hong, Gong, Zhi-guo, Zhao, Jia-min, Yang, Xiao-lin, Qu, Gang-gang, Hasi, Su-rong, Bai, Yu-ting, Cao, Jin-shan
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Sprache:eng
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Zusammenfassung:Hen egg low-density lipoprotein (heLDL), as alternative of serum-derived LDL, was used as drug delivery system of ceftiofur (CEF). The CEF-loaded hen egg low-density lipoprotein (CEF-heLDL) with complete apolipoprotein structure and high drug loading rate was synthesized, possesses suitable particle size. CEF-heLDL undergoes cellular uptake and colocalizes with lysosomes in vitro. An intracellular infection model of the bovine endometrial epithelial cells and a coeliac-induced inflammation model of mice by Staphylococcus aureus (S. aureus) were established, and significantly lower intracellular S. aureus levels of CEF-heLDL group than CEF-free group (P 
ISSN:0141-8130
1879-0003
1879-0003
DOI:10.1016/j.ijbiomac.2024.134840