Diagnostic accuracy of a machine learning algorithm using point-of-care high-sensitivity cardiac troponin I for rapid rule-out of myocardial infarction: a retrospective study

Point-of-care (POC) high-sensitivity cardiac troponin (hs-cTn) assays have been shown to provide similar analytical precision despite substantially shorter turnaround times compared with laboratory-based hs-cTn assays. We applied the previously developed machine learning based personalised Artificia...

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Veröffentlicht in:The Lancet. Digital health 2024-10, Vol.6 (10), p.e729-e738
Hauptverfasser: Toprak, Betül, Solleder, Hugo, Di Carluccio, Eleonora, Greenslade, Jaimi H, Parsonage, William A, Schulz, Karen, Cullen, Louise, Apple, Fred S, Ziegler, Andreas, Blankenberg, Stefan, Stephensen, Laura, Brownlee, Emily, McCormick, Ellyse, Fincher, Gavin, Hall, Emma J., Hancock, Rebecca, Gaikwad, Niranjan, Gangathimmaiah, Vinay, Hamilton-Craig, Christian, Hobbins-King, Andrew, Keijzers, Gerben, Bayat, Maryam Khorramshahi, Mahmoodi, Ehsan, Perez, Siegfried, Ranasinghe, Isuru, Staib, Andrew, Zournazi, Anna, Than, Martin
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Sprache:eng
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Zusammenfassung:Point-of-care (POC) high-sensitivity cardiac troponin (hs-cTn) assays have been shown to provide similar analytical precision despite substantially shorter turnaround times compared with laboratory-based hs-cTn assays. We applied the previously developed machine learning based personalised Artificial Intelligence in Suspected Myocardial Infarction Study (ARTEMIS) algorithm, which can predict the individual probability of myocardial infarction, with a single POC hs-cTn measurement, and compared its diagnostic performance with standard-of-care pathways for rapid rule-out of myocardial infarction. We retrospectively analysed pooled data from consecutive patients of two prospective observational cohorts in geographically distinct regions (the Safe Emergency Department Discharge Rate cohort from the USA and the Suspected Acute Myocardial Infarction in Emergency cohort from Australia) who presented to the emergency department with suspected myocardial infarction. Patients with ST-segment elevation myocardial infarction were excluded. Safety and efficacy of direct rule-out of myocardial infarction by the ARTEMIS algorithm (at a pre-specified probability threshold of
ISSN:2589-7500
2589-7500
DOI:10.1016/S2589-7500(24)00191-2