Implantable Microneedle‐Mediated Eradication of Postoperative Tumor Foci Mitigates Glioblastoma Relapse

Glioblastoma multiforme (GBM) remains incurable despite multimodal treatments after surgical debulking. Almost all patients with GBM relapse within a narrow margin (2–3 cm) of the initial resected lesion due to the unreachable residual cancerous cells. Here, a completely biodegradable microneedle fo...

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Veröffentlicht in:Advanced materials (Weinheim) 2024-10, Vol.36 (40), p.e2409857-n/a
Hauptverfasser: Zhang, Yulin, Fang, Zezheng, Liu, Zejuan, Xi, Kaiyan, Zhang, Yi, Zhao, Dawang, Feng, Fan, Geng, Humin, Liu, Minglu, Lou, Jingzhao, Chen, Chen, Zhang, Yanmin, Wu, Zimei, Xu, Feng, Jiang, Xinyi, Ni, Shilei
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Sprache:eng
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Zusammenfassung:Glioblastoma multiforme (GBM) remains incurable despite multimodal treatments after surgical debulking. Almost all patients with GBM relapse within a narrow margin (2–3 cm) of the initial resected lesion due to the unreachable residual cancerous cells. Here, a completely biodegradable microneedle for surgical cavity delivery glioblastoma‐associated macrophages (GAMs)‐activating immune nano‐stimulator that mitigates glioblastoma relapse is reported. The residual tumor lesion‐directed biocompatible microneedle releases the nano‐stimulator and toll‐like receptor 9 agonist in a controlled manner until the microneedles completely degrade over 1 week, efferently induce in situ phonotypic shifting of GAMs from anti‐ to pro‐inflammatory and the tumor recurrence is obviously inhibited. The implantable microneedles offer a significant improvement over conventional transdermal ones, as they are 100% degradable, ensuring safe application within surgical cavities. It is also revealed that the T cells are recruited to the tumor niche as the GAMs initiate anti‐tumor response and eradicate residual GBM cells. Taken together, this work provides a potential strategy for immunomodulating the postoperative tumor niche to mitigate tumor relapse in GBM patients, which may have broad applications in other malignancies with surgical intervention. A biodegradable and immunomodulatory microneedle (GMAN@CMN) is reported in this work. As an adjunctive strategy for the treatment of GBM, GMAN@CMN initiates anti‐tumor immunity and effectively prevents GBM postoperative relapse. The implantable microneedle even holds potential when the tumor invades vital regions that cannot be surgically resected.
ISSN:0935-9648
1521-4095
1521-4095
DOI:10.1002/adma.202409857