APE1: A critical focus in neurodegenerative conditions

The global growth of the aging population has resulted in an increased prevalence of neurodegenerative diseases, characterized by the progressive loss of central nervous system (CNS) structure and function. Given the high incidence and debilitating nature of neurodegenerative diseases, there is an urgent need to identify potential biomarkers and novel therapeutic targets thereof. Apurinic/apyrimidinic endonuclease 1 (APE1), has been implicated in several neurodegenerative diseases, as having a significant role. Abnormal APE1 expression has been observed in conditions including Alzheimer’s disease, stroke, amyotrophic lateral sclerosis, Parkinson’s disease, Huntington’s disease, and epilepsy. However, whether this dysregulation is protective or harmful remains unclear. This review aims to comprehensively review the current understanding of the involvement of APE1 in neurodegenerative diseases. [Display omitted] •Novel evidence establishes a connection between APE1 dysregulation and the progression of neurodegenerative diseases.•The modulation of APE1 activity is evaluated as a potential therapeutic strategy for ameliorating neurodegenerative diseases.•APE1 could be a potential biological marker in neurodegenerative diseases.