Autologous exosomes loaded with a rationally designed photosensitizer for enhanced photodynamic therapy

We present generalizing statistical surrogate models to select an optimized photosensitizer, TPP, which is subsequently loaded into autologous exosomes by ultrasonic mixing to achieve tumor targeting with enhanced therapeutic efficacy by photodynamic therapy (PDT). This work contributes to the exploration of PDT enhancement strategies, and provides new prospects for using autologous exosomes as a delivery system. We present generalizing statistical surrogate models to optimize photosensitizer selection and enhance photodynamic therapy efficacy by encapsulating it into autologous exosomes.