Heterochiral π-Stacking Dimerization of Helical Secondary Structures with Emerging Supramolecular Chirality

A specific interface mode type was observed between helical secondary structures, in which a left-handed (M) helix binds specifically to a right-handed (P) helix along the helical axis, leading to the formation of discrete heterochiral helical dimers. Moreover, a concealed supramolecular chirality within the meso-supramolecular dimers was unexpectedly discovered by chiral induction, and was further underpinned by covalent meso-helix structures.