Why Was the Azithromycin “for Life” Trial Necessary?

In 2009, a cluster-randomized trial showed a 49% reduction in all-cause mortality among Ethiopian children 1 to 9 years of age in the year after mass distribution of a single dose of azithromycin for trachoma prevention — a reduction that was sustained over the following 26 months. 1 This remarkable...

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Veröffentlicht in:	The New England journal of medicine 2024-08, Vol.391 (8), p.760-762
Hauptverfasser:	Maitland, Kathryn, Walker, A. Sarah
Format:	Artikel
Sprache:	eng
Schlagworte:	Age Age composition Anti-Bacterial Agents - administration & dosage Anti-Bacterial Agents - adverse effects Antibiotics Antimicrobial agents Azithromycin Azithromycin - administration & dosage Azithromycin - adverse effects Babies Bacterial Infections Bacterial Infections - mortality Bacterial Infections - prevention & control Chemoprevention - adverse effects Chemoprevention - methods Chemoprevention - statistics & numerical data Child Mortality Child, Preschool Childhood Diseases Children & youth Disease prevention Drug resistance Drug Resistance, Bacterial Global Health Humans Infant Infant Mortality Infections Infectious Disease Infectious Disease General Malaria Mass Drug Administration - adverse effects Mass Drug Administration - methods Mass Drug Administration - statistics & numerical data Niger - epidemiology Pediatrics Pediatrics General Prophylaxis Randomized Controlled Trials as Topic Seasonal distribution Trachoma
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Zusammenfassung:	In 2009, a cluster-randomized trial showed a 49% reduction in all-cause mortality among Ethiopian children 1 to 9 years of age in the year after mass distribution of a single dose of azithromycin for trachoma prevention — a reduction that was sustained over the following 26 months. 1 This remarkable finding led to further multinational cluster-randomized trials examining mass distribution of azithromycin for children 1 to 59 months of age in trachoma-endemic areas of Niger, Tanzania, and Malawi (the Macrolides Oraux pour Réduire les Décès avec un Oeil sur la Résistance [MORDOR] trial) 2 and such distribution combined with seasonal malaria prophylaxis . . .
ISSN:	0028-4793 1533-4406 1533-4406
DOI:	10.1056/NEJMe2407000