Platelet-rich Plasma as a Treatment Modality for Wound Healing: An Open Randomized Controlled Trial
Unlike conventional management protocols, like dressings, wound debridement, and skin grafting that do not facilitate healing, platelet-rich plasma (PRP) directly feeds growth factors to enhance wound healing. An open randomized controlled trial with a sample size of 60 was carried out on patients w...
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| Veröffentlicht in: | Journal of the Association of Physicians of India 2024-08, Vol.72 (8), p.e26 |
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| container_title | Journal of the Association of Physicians of India |
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| creator | Jose, Anna Mary Mahakalkar, Chandrashekhar C |
| description | Unlike conventional management protocols, like dressings, wound debridement, and skin grafting that do not facilitate healing, platelet-rich plasma (PRP) directly feeds growth factors to enhance wound healing.
An open randomized controlled trial with a sample size of 60 was carried out on patients with a wound surface area ≤10 × 10 cm
with 30 participants in each. The PRP group (PRPG) was given autologous PRP using the infiltration technique, and the control group (CG) was treated using conventional dressings.
The PRPG showed a reduction from 1421 to 661 mm
, whereas the CG showed a decrease from 1710 to 1478 mm
on day 30. The PRP group had a decreased hospital stay (
= 14) in comparison to the CG (
= 17.5 days). The rate of epithelization (mean) is 11.12 mm
/day in the CG and 34.026 mm
/day in the PRPG.
Platelet-rich plasma (PRP) can be considered a primary modality for wound management because of decreased length of hospital stay, analgesic effects, fastened rate of healing, and absence of adverse reactions. |
| doi_str_mv | 10.59556/japi.72.0428 |
| format | Article |
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An open randomized controlled trial with a sample size of 60 was carried out on patients with a wound surface area ≤10 × 10 cm
with 30 participants in each. The PRP group (PRPG) was given autologous PRP using the infiltration technique, and the control group (CG) was treated using conventional dressings.
The PRPG showed a reduction from 1421 to 661 mm
, whereas the CG showed a decrease from 1710 to 1478 mm
on day 30. The PRP group had a decreased hospital stay (
= 14) in comparison to the CG (
= 17.5 days). The rate of epithelization (mean) is 11.12 mm
/day in the CG and 34.026 mm
/day in the PRPG.
Platelet-rich plasma (PRP) can be considered a primary modality for wound management because of decreased length of hospital stay, analgesic effects, fastened rate of healing, and absence of adverse reactions.</description><identifier>ISSN: 0004-5772</identifier><identifier>DOI: 10.59556/japi.72.0428</identifier><identifier>PMID: 39163067</identifier><language>eng</language><publisher>India</publisher><subject>Aged ; Bandages ; Female ; Humans ; Length of Stay - statistics & numerical data ; Male ; Middle Aged ; Platelet-Rich Plasma ; Treatment Outcome ; Wound Healing</subject><ispartof>Journal of the Association of Physicians of India, 2024-08, Vol.72 (8), p.e26</ispartof><rights>Journal of the Association of Physicians of India 2024.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,27901,27902</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/39163067$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Jose, Anna Mary</creatorcontrib><creatorcontrib>Mahakalkar, Chandrashekhar C</creatorcontrib><title>Platelet-rich Plasma as a Treatment Modality for Wound Healing: An Open Randomized Controlled Trial</title><title>Journal of the Association of Physicians of India</title><addtitle>J Assoc Physicians India</addtitle><description>Unlike conventional management protocols, like dressings, wound debridement, and skin grafting that do not facilitate healing, platelet-rich plasma (PRP) directly feeds growth factors to enhance wound healing.
An open randomized controlled trial with a sample size of 60 was carried out on patients with a wound surface area ≤10 × 10 cm
with 30 participants in each. The PRP group (PRPG) was given autologous PRP using the infiltration technique, and the control group (CG) was treated using conventional dressings.
The PRPG showed a reduction from 1421 to 661 mm
, whereas the CG showed a decrease from 1710 to 1478 mm
on day 30. The PRP group had a decreased hospital stay (
= 14) in comparison to the CG (
= 17.5 days). The rate of epithelization (mean) is 11.12 mm
/day in the CG and 34.026 mm
/day in the PRPG.
Platelet-rich plasma (PRP) can be considered a primary modality for wound management because of decreased length of hospital stay, analgesic effects, fastened rate of healing, and absence of adverse reactions.</description><subject>Aged</subject><subject>Bandages</subject><subject>Female</subject><subject>Humans</subject><subject>Length of Stay - statistics & numerical data</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Platelet-Rich Plasma</subject><subject>Treatment Outcome</subject><subject>Wound Healing</subject><issn>0004-5772</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2024</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNo1kDtPwzAUhT2AaCmMrMgjS4oTP8NWVUCRiopQJMboJrmBVI4d7HQov55IlOk89OkMh5CblC1lLqW638PQLXW2ZCIzZ2TOGBOJ1DqbkcsY94zxnPPsgsx4nirOlJ6T-s3CiBbHJHT1F51S7IFCpECLgDD26Eb66huw3XikrQ_0wx9cQzc4Ne7zga4c3Q3o6Du4xvfdDzZ07d0YvLWTLUIH9oqct2AjXp90QYqnx2K9Sba755f1apsMUumkSlutqrY2QmHTZCiYAQOMZ7rWTCpTITegdStEmopccsa14UqC5ooJU7V8Qe7-Zofgvw8Yx7LvYo3WgkN_iCVnuTCZkiKd0NsTeqh6bMohdD2EY_n_C_8FRwFhqQ</recordid><startdate>202408</startdate><enddate>202408</enddate><creator>Jose, Anna Mary</creator><creator>Mahakalkar, Chandrashekhar C</creator><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>7X8</scope></search><sort><creationdate>202408</creationdate><title>Platelet-rich Plasma as a Treatment Modality for Wound Healing: An Open Randomized Controlled Trial</title><author>Jose, Anna Mary ; Mahakalkar, Chandrashekhar C</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-p567-b1f76bfc846edd2e408a8a0327c70568be38a77f441149530378365a736048bf3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2024</creationdate><topic>Aged</topic><topic>Bandages</topic><topic>Female</topic><topic>Humans</topic><topic>Length of Stay - statistics & numerical data</topic><topic>Male</topic><topic>Middle Aged</topic><topic>Platelet-Rich Plasma</topic><topic>Treatment Outcome</topic><topic>Wound Healing</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Jose, Anna Mary</creatorcontrib><creatorcontrib>Mahakalkar, Chandrashekhar C</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of the Association of Physicians of India</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Jose, Anna Mary</au><au>Mahakalkar, Chandrashekhar C</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Platelet-rich Plasma as a Treatment Modality for Wound Healing: An Open Randomized Controlled Trial</atitle><jtitle>Journal of the Association of Physicians of India</jtitle><addtitle>J Assoc Physicians India</addtitle><date>2024-08</date><risdate>2024</risdate><volume>72</volume><issue>8</issue><spage>e26</spage><pages>e26-</pages><issn>0004-5772</issn><abstract>Unlike conventional management protocols, like dressings, wound debridement, and skin grafting that do not facilitate healing, platelet-rich plasma (PRP) directly feeds growth factors to enhance wound healing.
An open randomized controlled trial with a sample size of 60 was carried out on patients with a wound surface area ≤10 × 10 cm
with 30 participants in each. The PRP group (PRPG) was given autologous PRP using the infiltration technique, and the control group (CG) was treated using conventional dressings.
The PRPG showed a reduction from 1421 to 661 mm
, whereas the CG showed a decrease from 1710 to 1478 mm
on day 30. The PRP group had a decreased hospital stay (
= 14) in comparison to the CG (
= 17.5 days). The rate of epithelization (mean) is 11.12 mm
/day in the CG and 34.026 mm
/day in the PRPG.
Platelet-rich plasma (PRP) can be considered a primary modality for wound management because of decreased length of hospital stay, analgesic effects, fastened rate of healing, and absence of adverse reactions.</abstract><cop>India</cop><pmid>39163067</pmid><doi>10.59556/japi.72.0428</doi></addata></record> |
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| ispartof | Journal of the Association of Physicians of India, 2024-08, Vol.72 (8), p.e26 |
| issn | 0004-5772 |
| language | eng |
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| source | MEDLINE; Alma/SFX Local Collection; EZB Electronic Journals Library |
| subjects | Aged Bandages Female Humans Length of Stay - statistics & numerical data Male Middle Aged Platelet-Rich Plasma Treatment Outcome Wound Healing |
| title | Platelet-rich Plasma as a Treatment Modality for Wound Healing: An Open Randomized Controlled Trial |
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