Platelet-rich Plasma as a Treatment Modality for Wound Healing: An Open Randomized Controlled Trial

Unlike conventional management protocols, like dressings, wound debridement, and skin grafting that do not facilitate healing, platelet-rich plasma (PRP) directly feeds growth factors to enhance wound healing. An open randomized controlled trial with a sample size of 60 was carried out on patients with a wound surface area ≤10 × 10 cm with 30 participants in each. The PRP group (PRPG) was given autologous PRP using the infiltration technique, and the control group (CG) was treated using conventional dressings. The PRPG showed a reduction from 1421 to 661 mm , whereas the CG showed a decrease from 1710 to 1478 mm on day 30. The PRP group had a decreased hospital stay ( = 14) in comparison to the CG ( = 17.5 days). The rate of epithelization (mean) is 11.12 mm /day in the CG and 34.026 mm /day in the PRPG. Platelet-rich plasma (PRP) can be considered a primary modality for wound management because of decreased length of hospital stay, analgesic effects, fastened rate of healing, and absence of adverse reactions.