A novel NIR fluorescent probe for copper() imaging in Parkinson's disease mouse brain

A novel NIR fluorescent probe for copper() imaging in Parkinson's disease mouse brain

Abnormal copper ion (Cu 2+ ) levels are considered to be one of the pathological factors of Parkinson's disease (PD), but the internal relationship between Cu 2+ and PD progression remains elusive. Visualizing Cu 2+ in the brain will be pivotal for comprehending the underlying pathophysiologica...

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Veröffentlicht in:Chemical science (Cambridge) 2024-08, Vol.15 (32), p.1382-1389
Hauptverfasser: Chen, Jianmei, Luo, Rongqing, Li, Shuang, Shao, Jinping, Wang, Ting, Xie, Shumei, Xu, Li, You, Qiuyun, Feng, Shumin, Feng, Guoqiang
Format: Artikel
Sprache:eng
Schlagworte:
Blood-brain barrier
Brain
Cerebral cortex
Chemistry
Copper
Fluorescent indicators
Medical imaging
Near infrared radiation
Parkinson's disease
Zebrafish
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Zusammenfassung:Abnormal copper ion (Cu 2+ ) levels are considered to be one of the pathological factors of Parkinson's disease (PD), but the internal relationship between Cu 2+ and PD progression remains elusive. Visualizing Cu 2+ in the brain will be pivotal for comprehending the underlying pathophysiological processes of PD. In this work, a near-infrared (NIR) fluorescent probe, DDAO-Cu , capable of detecting Cu 2+ with exceptional sensitivity (about 1.8 nM of detection limit) and selectivity, rapid response (
ISSN:2041-6520
2041-6539
DOI:10.1039/d4sc03445g