From π‑Conjugated Rods to Shape-Persistent Rings, Wheels, and Ladders: The Question of Rigidity

Conspectus Rigid-rod oligomers and polymers are mostly based on (hetero)­aromatic rings connected with each other, either directly or via ethynylene or butadiynylene linkers, or by a combination of both structural elements. Although they are much more rigid than vinyl polymers, they exhibit considerable structural flexibility, often more than would be expected merely from their chemical structure. This disparity holds for both linear as well as for cyclic structures. The flexibility of rigid-rod polymers, which is directly observable for defined oligomers of different lengths at the solid–liquid interface by means of scanning-tunneling microscopy, also impacts their optical and electronic properties. The flexibility can be used, for example, to control whether an oligomer with two different fluorescent end-groups emits from either the one or the other. The flexibility of shape-persistent macrocycles also has an impact on the overall thermal stability of mechanically interlocked molecular architectures. However, the degree of flexibility can be reduced when rigid struts are covalently mounted into the inside of the rings, leading to the formation of so-called molecular spoked wheels. The combination of these two elementsrings and rodsstiffens both of them: the ring perimeter is prevented from collapsing and the internal rods from bending. These compounds have been further developed as platform molecules, where three spokes stiffen the ring and together form a tripod-like platform, while a fourth arm pointsafter adsorption to a solid substrateabove the plane of the molecule. This pillar makes it possible to decouple a functional group at the end of the arm from the surface. Rigidity enhancement by the introduction of rigid spacer elements can also be applied to the case of rigid-rod polymers and is visualized by sophisticated molecular dynamics simulations. In this case, formation of single-stranded oligomers and polymers, and a subsequent zipping reaction to form ladder-like structures, directly allows, by means of single-molecule fluorescence spectroscopy, a comparison of the single- and double-stranded molecules. In particular in the case of the polymers, which can be up to 100 nm in length, the enhancement of rigidity is quite remarkable. Overall, the covalent connection of two or more rigid molecular entities has a self-reinforcing effect: all parts of the molecule gain rigidity. Since overall synthetic yields for such complex high-molecular weight