Copper(I) Iodide-Catalyzed Perfluoroalkoxylation Reaction of Alkyl Halides

We report an efficient perfluoroalkoxylation reaction of alkyl halides catalyzed by copper­(I) iodide (CuI), which facilitates the simultaneous activation of both perfluoroalkoxide and alkyl halides. This methodology is tolerant of a wide range of functional groups and eliminates the need for costly metal reagents. The reaction is conducted in a single step under mildly practical conditions.