A fatty acid switch drives ferroptosis in EMT
Ferroptosis is mediated by toxic accumulation of lipid peroxides. A new study reports that the transcription factor ZEB1 drives ferroptosis sensitivity by regulating the synthesis of highly oxidizable poly-unsaturated fatty acids. This creates a selective vulnerability that can be exploited to elimi...
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| Veröffentlicht in: | Nature cell biology 2024-09, Vol.26 (9), p.1375-1376 |
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| container_title | Nature cell biology |
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| creator | Winkelkotte, Alina M. Schulze, Almut |
| description | Ferroptosis is mediated by toxic accumulation of lipid peroxides. A new study reports that the transcription factor ZEB1 drives ferroptosis sensitivity by regulating the synthesis of highly oxidizable poly-unsaturated fatty acids. This creates a selective vulnerability that can be exploited to eliminate aggressive mesenchymal cancer cells. |
| doi_str_mv | 10.1038/s41556-024-01483-y |
| format | Article |
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| ispartof | Nature cell biology, 2024-09, Vol.26 (9), p.1375-1376 |
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| source | MEDLINE; Nature Journals Online; SpringerLink Journals - AutoHoldings |
| subjects | 631/337/572 631/45/287/1183 Animals Biology Biomedical and Life Sciences Breast cancer Cancer Research Cell Biology Cell death Developmental Biology Enzymes Epithelial-Mesenchymal Transition Fatty acids Fatty Acids - metabolism Ferroptosis Ferroptosis - genetics Genotype & phenotype Humans Life Sciences Lipids Medical research Metabolism Metastasis News & Views news-and-views Peroxides Polyunsaturated fatty acids Stem Cells Transcription factors Trends Tumors |
| title | A fatty acid switch drives ferroptosis in EMT |
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