A fatty acid switch drives ferroptosis in EMT

Ferroptosis is mediated by toxic accumulation of lipid peroxides. A new study reports that the transcription factor ZEB1 drives ferroptosis sensitivity by regulating the synthesis of highly oxidizable poly-unsaturated fatty acids. This creates a selective vulnerability that can be exploited to elimi...

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Veröffentlicht in:	Nature cell biology 2024-09, Vol.26 (9), p.1375-1376
Hauptverfasser:	Winkelkotte, Alina M., Schulze, Almut
Format:	Artikel
Sprache:	eng
Schlagworte:	631/337/572 631/45/287/1183 Animals Biology Biomedical and Life Sciences Breast cancer Cancer Research Cell Biology Cell death Developmental Biology Enzymes Epithelial-Mesenchymal Transition Fatty acids Fatty Acids - metabolism Ferroptosis Ferroptosis - genetics Genotype & phenotype Humans Life Sciences Lipids Medical research Metabolism Metastasis News & Views news-and-views Peroxides Polyunsaturated fatty acids Stem Cells Transcription factors Trends Tumors
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Zusammenfassung:	Ferroptosis is mediated by toxic accumulation of lipid peroxides. A new study reports that the transcription factor ZEB1 drives ferroptosis sensitivity by regulating the synthesis of highly oxidizable poly-unsaturated fatty acids. This creates a selective vulnerability that can be exploited to eliminate aggressive mesenchymal cancer cells.
ISSN:	1465-7392 1476-4679 1476-4679
DOI:	10.1038/s41556-024-01483-y