Model of Accelerated Aging in CB6F2 Mice Induced by Ionizing Radiation

A model for accelerated aging in mice was developed: CB6F2 mice aged 39-45 days were exposed to fractionated 4-fold relatively uniform γ-radiation ( 137 Cs, 0.98 Gy/min) at a total dose of 6.8 Gy. Radiation exposure led to delayed active growth, leukopenia, and lymphopenia for over 1 year during the...

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Veröffentlicht in:	Bulletin of experimental biology and medicine 2024-07, Vol.177 (3), p.363-367
Hauptverfasser:	Yakunchikova, E. A., Yurova, M. N., Drachyov, I. S., Radetskaya, E. A., Altukhov, K. V., Semenov, A. L., Panchenko, A. V., Tyndyk, M. L., Bykov, V. N., Fedoros, E. I.
Format:	Artikel
Sprache:	eng
Schlagworte:	Aging Aging - radiation effects Aging, Premature - etiology Aging, Premature - genetics Aging, Premature - pathology Animals Biomedical and Life Sciences Biomedicine Cachexia Cachexia - etiology Cachexia - pathology Cell Biology Cell cycle Cesium Radioisotopes Drug dosages Female Females Gamma Rays - adverse effects Hematology Hypothesis testing Internal Medicine Ionizing radiation Laboratory Medicine Leukopenia Longevity - radiation effects Lymphopenia Male Males Medical research Mice Oncology Pathogenesis Pathology Post-radiation Radiation Radiation, Ionizing Research centers Software γ Radiation
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Zusammenfassung:	A model for accelerated aging in mice was developed: CB6F2 mice aged 39-45 days were exposed to fractionated 4-fold relatively uniform γ-radiation ( 137 Cs, 0.98 Gy/min) at a total dose of 6.8 Gy. Radiation exposure led to delayed active growth, leukopenia, and lymphopenia for over 1 year during the post-radiation period. The death of irradiated males and females occurred significantly earlier than in control group animals. Median lifespans in the experimental group were 35-38% lower than in the control group ( p
ISSN:	0007-4888 1573-8221 1573-8221
DOI:	10.1007/s10517-024-06190-0