Joint effects of sleep disturbance and renal function impairment on incident new‐onset severe metabolic dysfunction‐associated steatotic liver disease

Aim To elucidate the effects of sleep parameters and renal function on the risk of developing new‐onset severe metabolic dysfunction‐associated steatotic liver disease (MASLD). Materials and Methods The primary analysis involved a cohort of 305 257 participants. Multivariable Cox models were employed to calculate hazard ratios and 95% confidence intervals. Traditional mediation and two‐step Mendelian randomization (MR) analyses were conducted to assess the associations and mediating roles of renal function indicators between sleep and new‐onset severe MASLD. Results Poor sleep score and renal function biomarker score (RFS) were associated with an increased risk of new‐onset severe MASLD (all ptrend